High-frequency vs. Low-frequency vs. Sham DMPFC-rTMS for Major Depression
Not Applicable
- Conditions
- Depression
- Registration Number
- NCT02702154
- Lead Sponsor
- University Health Network, Toronto
- Brief Summary
This trial will compare the efficacy and tolerability of 20 Hz vs. 1 Hz vs. sham repetitive transcranial magnetic stimulation targeting the dorsomedial prefrontal cortex, delivered twice daily over 15 days, in patients with a diagnosis of major depressive disorder. The trial will include structural and functional MRI, EEG, and behavioral measures obtained before, during, and after treatment.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 120
Inclusion Criteria
Not provided
Exclusion Criteria
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method HAM-D17 score Baseline, after each week (10 sessions) of treatment, and 2, 6, and 12 weeks post-treatment Outcome measured by a change in HAM-D17 score from baseline to 2 weeks post-treatment. A 50% improvement in the score is considered a response to rTMS. A final score of \<8 is categorized as remission.
- Secondary Outcome Measures
Name Time Method Beck anxiety inventory Baseline, after each week (10 sessions) of treatment, and 2, 6, and 12 weeks post-treatment Beck Depression Inventory-II Baseline, after each week (10 sessions) of treatment, and 2, 6, and 12 weeks post-treatment
Trial Locations
- Locations (1)
Toronto Western Hospital
🇨🇦Toronto, Ontario, Canada
Toronto Western Hospital🇨🇦Toronto, Ontario, Canada