NCT01029223撤回4 期
The Influence of Heart Rate Reduction Upon Central Arterial Pressure in Younger and Older Healthy Individuals
Bayside Health0 个研究点目标入组 42 人开始时间: 2008年10月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 撤回
- 发起方
- 入组人数
- 42
- 主要终点
- central and peripheral arterial and pulse wave velocity
研究概览
简要总结
The purpose of this study is to determine the effect of slowing heart rate upon both central and peripheral blood pressures using a medication called Ivabradine which slows heart rate without affecting heart contraction, and to compare the effects of ivabradine to a traditional blood pressure lowering medication called metoprolol (which is a beta-blocker).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Aged 18 - 25 years OR
- •Aged > 60 years
- •Exclusion Criteria
- •Chronic disease
- •Unable to give informed consent
- •Treated or untreated systemic arterial hypertension (SBP > 160 mmHg and/or DBP > 90 mmHg)
- •Resting bradycardia (heart rate < 60 beats/minute)
- •Pregnancy or active lactation
排除标准
- 未提供
研究组 & 干预措施
ivabradine
Experimental
干预措施: ivabradine (Drug)
metoprolol
Experimental
干预措施: metoprolol (Drug)
placebo
Placebo Comparator
干预措施: placebo (Drug)
结局指标
主要结局
central and peripheral arterial and pulse wave velocity
时间窗: baseline, and 4 hours following the administration of placebo, metoprolol or ivabradine.
次要结局
- Central pulse pressure(Baseline measurements of central and peripheral arterial and pulse wave velocity will be made at baseline, and 4 hours following the administration of either placebo, metoprolol or ivabradine.)
研究者
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