Memory Inhibition and Delayed Onset Post-traumatic Stress Disorder in Older Subjects

Not Applicable

Completed

• Conditions: Post-Traumatic Stress Disorder in Old Age
• Interventions: Other: Post Traumatic Stress Disorder

• Registration Number: NCT03897855
• Lead Sponsor: Centre Hospitalier de Niort

Brief Summary

In the elderly, we can see a post-traumatic syndrome associated with an event that occurred before old age that had not previously manifested or not fully manifested.

This little-known pathology and notable psychiatric co-morbidities (depression, anxiety) can take in elderly subjects different masks that interfere with diagnosis and treatment.

The data in the literature suggest that this Post-Traumatic Stress Disorder with Delayed Expression (TSPT-R) may be related to a deficiency of the executive functions of inhibition, and more particularly a deficit of mental memory inhibition and therefore the removal of unwanted memories.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-03-29
• Study First Submitted QC: 2019-03-29
• Study Start: 2019-04-01
• Study First Posted: 2019-04-01
• Primary Completion: 2019-04-15
• Study Completion: 2021-03-26
• Status Verified: 2021-07
• Last Update Submitted: 2021-07-29
• Last Update Posted: 2021-07-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Regarding the constitution of the group patient (TSPT-R):

• Subjects 65 years of age or older
• Clinical diagnosis of delayed-onset PTSD according to DSM-5 criteria after 65 years
• The traumatic event must have taken place at the latest before 65 years
• Affiliated person or beneficiary of a social security scheme.
• Written consent before any examination required by research)

Regarding the constitution of the control group:

• Subjects 65 years of age or older
• No diagnosis of PTSD (delayed or not) or history of PTSD (delayed or not)
• Affiliated person or beneficiary of a social security scheme.
• Written consent before any examination required by the research).

Exclusion Criteria

• For both groups:

• Acute or chronic cognitive impairment known

• GRECO MMSE pathological score less than or equal to the pathological threshold weighted according to level of education and age, namely:

  • 22 if no diploma
  • 23 if certificate of study
  • 25 if patent
  • 26 if bin or more
  • Remove one point at each threshold if age> 80 years

• Sensory or motor disorder preventing the passing of different tests

• Psychotic disorder

• Mood disorder in decompensation (for depression, HAD-D score equal to or greater than 11)

• Disorder of the use of a moderate or severe substance (except tobacco).

• Patients under guardianship or curatorship.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Patient (TSPT-R)	Post Traumatic Stress Disorder	Post Traumatic Stress Disorder
control	Post Traumatic Stress Disorder	No Post Traumatic Stress Disorder

Primary Outcome Measures

Name	Time	Method
Inhibition score measured by the Think / No-Think Test	1 month	the average of the inhibition score measured by the "Think / No-Think" test as defined by Anderson and Green (2001) and then reviewed by Anderson et al. in 2011

Trial Locations

Locations (1)

Centre Hospitalier de Niort; 🇫🇷 Niort, France