Improving transcranial direct current stimulation using model-based optimized electrode configurations.

Recruiting

Conditions: n.a.

Registration Number: NL-OMON38925

Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 30

Inclusion Criteria

Age 18-45 years
Righthanded

Exclusion Criteria

• Epilepsy, convulsion or seizure (TMS)
• Serious head trauma or brain surgery
• Large or ferromagnetic metal parts in the head (except for a dental wire)
• Implanted cardiac pacemaker or neurostimulator
• Pregnancy
• Skin diseases at intended electrode sites (EMG, tDCS)
• History or current presence of any neurologic or psychiatric disease
• Any prescribed medication that can alter cortical excitability (e.g. antiepileptics, tricyclic anti-depressives or benzodiazepines) or can have an influence on the participant*s vigilance or cognitive performance within two weeks prior to participation

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>This study will examine the changes in motor cortical excitability, defined as<br /><br>the size of MEPs measured via TMS and EMG, induced by anodal tDCS using<br /><br>different electrode configurations. Specifically, we predict that the<br /><br>model-based optimized configurations will lead to a larger increase in MEP size<br /><br>than the standard configuration from literature.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Furthermore, we expect that optimization based on both electric field strength<br /><br>and direction will lead to a larger increase in MEP size than optimization<br /><br>based on electric field strength alone.</p><br>