TCTR20190304003尚未招募未知
Caffeine and decaffeine coffee effects on serum uric acid and urate clearance, an open-label, randomized controlled prospective study.
适应症
试验速览
- 阶段
- 未知
- 状态
- 尚未招募
- 入组人数
- 45
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 20 Years 至 60 Years（—）
- 性别
- Male
入选标准
- •Healthy men were recruited from the internal medicine and health care staff of Naresuan University Hospital. The inclusion criteria were men, age 20-60 years old; having normal renal (GFR≥60 mL/min/1.73m2) and hepatic function tests (normal AST is ≤40unit/L in male, ALT is ≤41unit/L in male).
排除标准
- •The exclusion criteria were history of gout, hypertension(blood pressure ≥140/90mmHg), heart rate ≥100 beat/min, history of ischemic heart disease and arrhythmia; use of medication including ACEI or ARB, ethambutol, pyrazinamide, aspirin, cyclosporine, nicotinic acid, loop diuretic, etc. or nutritional supplement including vitamin C that affect the SUA level; estimated glomerular filtration rate (eGFR) less than 60 mL/min/1.73m2; abnormal serum aspartate aminotransferase (AST) and/or alanine transaminase (ALT); and 15% or more change in SUA during the control period(day0 to day7). However, if participants who be included and take coffee tablet have any serious side effects including severe disturbed normal sleep pattern, severe headache, blood pressure ≥140/90mmHg and heart rate ≥100 beat/min or arrhythmia , the participants will be withdrawal from this protocol.
研究者
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