Multimodal Imaging Evaluation of Myocardial Involvement in Immunocardiomyopathic Patients
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Progression of myocardial fibrosis and edema during follow-up period
研究概览
简要总结
Cardiac involvements in autoimmune diseases (AD) is common but underestimated and an early detection remains a clinical challenge for lacking of efficient imaging methods. The objective of the study was to investigate LV myocardial abnormalities in AD patients by multimodal cardiac imaging, including speckle-tracking echocardiology (STE), cardiac magnetic resonance imaging (CMRI) and positron emission tomography (PET).
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient is diagnosed with autoimmune diseases, including systemic lupus erythematosus (SLE), vasculitis, dermatomyositis, sjogren's syndrome, scleroderma, rheumatoid arthritis and IgG4 associated disease.
- •Patient is capable of complying with study procedures
排除标准
- •Patient is pregnant or nursing
- •Patient is complicated with congenital heart disease
- •Patient had cardiac surgery before
- •Patient is complicated with serious infections
- •Patient is complicated with organ failure
- •Patient is complicated with tumors
- •Patient is diagnosed indefinitely
- •Patient has been involved in other clinical trial
结局指标
主要结局
Progression of myocardial fibrosis and edema during follow-up period
时间窗: 1 year - 2 years
Late Gadolinium Enhanced, T1 mapping and T2 mapping tested by CMRI
Change in deformational parameters in echocardiography during follow-up period
时间窗: 6 months - 1 year - 2 years
global longitudinal strain (%), circumferential strain (%) and radial strain (%) measured by STE in autoimmune diseases
Change in myocardial perfusion during follow-up period
时间窗: 1 year - 2 years
SUVmax examined by PET
次要结局
未报告次要终点