Effects of intravenous lidocaine on somatosensory and motor evoked potentials during spine surgery
Completed
- Conditions
- Multilevel posterior spinal fusionMusculoskeletal Diseases
- Registration Number
- ISRCTN11684890
- Lead Sponsor
- Hospital for Special Surgery
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
1. Patients undergoing multi-level posterior spine fusions requiring both somatosensory and motor evoked potential monitoring
2. Ages within the age range of 18 – 70 years.
Exclusion Criteria
1. Allergy to any of the anesthetic medications included in the protocol
2. Current use of medication for Parkinson’s disease
3. Current psychotropic medication
4. History of cardiac arrhythmias
5. Non-English speaking
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Somatosensory evoked potential amplitude is measured using a Cadwell Elite intraoperative monitoring system, at 3-5 minute intervals<br>2. Motor evoked potentials threshold voltage is measured using a Cadwell Elite intraoperative monitoring system, at 10-20 minute intervals
- Secondary Outcome Measures
Name Time Method 1. Isoflurane concentration is measured using a General Electric Datex Ohmeda operating room patient monitor at 5 minute intervals<br>2. Heart rate is measured using a General Electric Datex Ohmeda operating room patient monitor at 5 minute intervals<br>3. Blood pressure is measured using a General Electric Datex Ohmeda operating room patient monitor at 5 minute intervals<br>4. Temperature is measured using a General Electric Datex Ohmeda operating room patient monitor at 5 minute intervals<br>5. Estimated blood loss is measured at the conclusion of the procedure based on cell salvage system data, irrigation and intraoperative blood administration