The Effects of Two Psychological Intervention Techniques, Self-hypnosis and Johrei Healing Method, on Quality of Life, Psychological Well-being, EEG Measures and Various Immunological Measures Including CD4+ Counts in Early HIV: a Randomly Controlled Pilot Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 22
- 试验地点
- 2
- 主要终点
- CD4 T-cell counts
研究概览
简要总结
This study examines the hypothesis that psychological interventions have beneficial effects on quality of life including psychological well-being and disease progression in early HIV patients recieving no medication.
详细描述
Hypothesis
This investigation is based upon the hypothesis that psychological intervention may counteract the detrimental effects of stress both on psychological well-being and on general health.
Background: HIV infection may be considered to be a life-long biological and psychological stressor leading to detrimental outcomes associated with disease progression. Stress reduction in these patients may have beneficial effects through delaying disease progression via the proposed interactive psycho-neuro-endocrine-immune network.
Inclusion Criteria:
HIV infected individuals CD4 T-cell counts above 200 cells/mcl Receiving no anti-retroviral drugs Individuals who signed the informed consent form
Investigative approach: Self-hypnosis and a Japanese non-touching, laying-on-of hands-like technique, called Johrei, were used to investigate the effects of psychological intervention upon immune parameters (especially in CD4 counts) associated with disease progression along with phenomenological associations between stress perception and stress hormone levels in HIV-infected patients receiving no medication.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Single (Participant)
盲法说明
Single blinded
入排标准
- 年龄范围
- 20 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •HIV infected
- •CD4 T-cell counts above 200 cells/mcl
- •Signed the informed consent form
排除标准
- •receiving anti-retroviral drugs
研究组 & 干预措施
Self-hypnosis
A course of four weekly 2-hour training sessions coupled with daily self-hypnosis practice was given to 13 participants with diagnosed HIV
干预措施: Hypnosis (Behavioral)
Johrei healing method
A course of four weekly 2-hour training sessions coupled with daily self-hypnosis practice was given to 9 participants with diagnosed HIV
干预措施: Hypnosis (Behavioral)
结局指标
主要结局
CD4 T-cell counts
时间窗: 4 weeks
Lab test
次要结局
- Endogenous hormone levels (cortisol, DHEA-S and melatonin)(4 weeks)
- Other immunological parameters (Viral load levels, NK cell counts)(4 weeks)
- Psychological questionnaires (Perceived Stress Scale (PSS), STAI, Beck depression Inventory (BDI))(4 weeks)
