A Prospective, Single Arm, Multicenter Clinical Study to Evaluate the Efficacy of Venetoclax Combined With Azacytidine or DA Regimen in Prevention the Relapse of Consecutive MRD Positive AML Patients
Overview
- Phase
- Phase 2
- Intervention
- Venetoclax, Azacitidine
- Conditions
- Acute Myeloid Leukemia
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
- Enrollment
- 20
- Locations
- 1
- Primary Endpoint
- relapse free survival
- Status
- Terminated
- Last Updated
- 4 months ago
Overview
Brief Summary
Measurable disease (MRD) plays an important role in the therapeutic efficacy and prognosis of acute myeloid leukemia (AML). Studies show that persistent MRD positivity after induction indicates that the patient has a higher risk of recurrence. Even if the patient is assessed as a low risk group, once there is persistent MRD positive, Allogeneic hematopoietic stem cell transplantation (allo HSCT) or clinical trials should be considered to improve the overall survival of patients. However, some patients cannot accept allo HSCT due to economic reasons or lack of suitable donors. How to prolong the recurrence free survival of these patients is still a great challenge. Platzbecker et al. applied azacytidine (AZA) monotherapy to AML patients with continuous MRD positive after combined chemotherapy. The results showed that the preemptive treatment of AZA could prevent or significantly delay the hematological relapse of MDS or AML patients with MRD positive. In addition, the application of venetoclax has significantly changed the therapeutic prospect of AML and provided new opportunities. Studies have shown that venetoclax can enhance the activity of anti HMA, cytarabine, idarubicin and other drugs. The curative effect of venetoclax combined with AZA in the treatment of elderly AML patients who are not suitable for intensive treatment is better than that of single AZA regimen, and the negative rate of MRD after induction treatment of venetoclax combined with HMA is higher (54-81%). Therefore, the investigators believe that for patients who continue to be MRD positive after induction and consolidation treatment, venetoclax based regimen may be an effective preemptive treatment regimen, which can prolong the relapse free time and overall survival of these patients
Detailed Description
In the study, 40 patients will be enrolled and treated with venotoclax combined AZA and DA regimen. Patients receive major response will be given venotoclax combined AZA regimen as maintenance treatment. The primary endpoint was 6 month relapse-free survival. Measurable residual disease (MRD) will be detected at the beginning of the therapy and after the therapy. The adverse effect will also be explored. Preemptive chemotherapy: regimen 1: azacytidine 75 mg/m2 d1-7，venetoclax: 100mg d1, 200mg d2, 400mg d3-21; regimen 2: daunorubicin：45mg/m2 d1-2, cytarabine:100mg/ m2 d1-5, venetoclax: 100mg d1, 200mg d2, 400mg d3-14; maintenance therapy: patient in regimen 1 group: azacytidine 75 mg/m2 d1-7，venetoclax: 400mg d1-14, for 4 cycles, patients in regimen 2 group: azacytidine 75 mg/m2 d1-7，venetoclax: 400mg d1-14, for 4 cycles.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Diagnosed acute myeloid leukemia
- •Received chemotherapy within 24 months and has completed the consolidation treatment plan
- •In complete remission
- •With MRD positive: abnormal myeloid cells in bone marrow ≥ 0.1%, or NPM1 gene mutation and other fusion gene positive(RUNX 1-RUNX1T 1、CBFB-MYH11 and DEK-NUP214), the PCR quantification ≥1%.
- •Age≥ 18 years #male or female
- •ECOG-PS score 0-2
- •Aboratory tests#within 7 days before chemotherapy# 1). Serum total bilirubin≤1.5xULN# 2). Serum AST and ALT≤2.5xULN 3). Serum creatinine≤2xULN# 4). Cardiac enzymes≤2xULN 5). Ejection fraction \>50% by ECHO#
- •Written informed consent
Exclusion Criteria
- •Hematological relapse (the proportion of blast cells in bone marrow is greater than 5%)
- •Receive hematopoietic stem cell transplantation within 4 weeks
- •Have been treated with venetoclax in the past 6 months (who can be enrolled after stopping for more than 6 months)
- •Suffering from malignant tumors of other organs (those requiring treatment)
- •Pregnant or lactating women
- •Active heart diseases
- •Severe active infection
- •Unfit for enrollment evaluated by investigator
Arms & Interventions
venetoclax pluse azacitidine arm
azacytidine 75 mg/m2 d1-7，venetoclax: 100mg d1, 200mg d2, 400mg d3-21
Intervention: Venetoclax, Azacitidine
venetoclax pluse DA arm
daunorubicin：45mg/m2 d1-2, cytarabine:100mg/ m2 d1-5, venetoclax: 100mg d1, 200mg d2, 400mg d3-14
Intervention: Venetoclax, daunorubicin, cytarabine
Outcomes
Primary Outcomes
relapse free survival
Time Frame: 6 months
survival from the preemptive therapy to relapse
Secondary Outcomes
- major response(3 months)
- relapse free survival(12 months)
- overall survival(1 year)