The Effects of Passive Heat Therapy in Patients With Chronic Kidney Disease
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- Renal Safety of Heat Therapy
Study Overview
Brief Summary
The objective of this proposal is to investigate the acute effects of whole-body passive heat therapy using far-infrared technology on vascular function, exercise capacity, and renal function in CKD patients. The central hypothesis is that an acute bout of whole-body passive heat therapy will be well-tolerated and lead to acute improvements in large blood vessel (macrovascular) function, small blood vessel (microvascular) function, and exercise capacity without significantly altering markers of acute kidney injury.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Other
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •for participants with CKD:
- •Age > 18 years old
- •Stage 2-4 CKD
Exclusion Criteria
- •for participants with CKD:
- •Unstable medical conditions characterized by frequent or unpredictable biological, chemical, or psychological changes
- •Uncontrolled hypertension
- •Current fluid restrictions
- •End stage kidney disease or currently on dialysis treatment
- •Body weight < 40kg
- •Exhibits any contraindications to exercise as per ACSM guidelines
- •Regular tobacco and/or nicotine use
- •History of heat-related illness
- •Participates in regular exercise and/or sauna use
- •Current hormone replacement therapy
- •Pacemaker or electro-medical implant
- •Persons with or at risk of intestinal disorders including gastroporesis
- •History of diverticula
- •Persons who have undergone surgical procedures in the GI tract
- •Swallowing disorders
- •Chron's disease
- •Current pregnancy
- •Inability to provide informed consent
Arms & Interventions
Experimental Arm: Whole-body Passive Heat Therapy (HT)
Heat therapy will be administered using an infrared sauna. The intervention duration will last 25 minutes at a temperature of 60°C.
Intervention: Whole-body Passive Heat Therapy (HT) (Procedure)
Experimental Arm: Whole-body Passive Heat Therapy (HT)
Heat therapy will be administered using an infrared sauna. The intervention duration will last 25 minutes at a temperature of 60°C.
Intervention: Thermoneutral Control (CON) (Procedure)
Outcomes
Primary Outcomes
Renal Safety of Heat Therapy
Time Frame: Change from baseline to 90 minutes after intervention
Change in urinary NGAL
Tolerability of Heat Therapy as Assessed using Validated Questionnaires of Thermal Perception
Time Frame: During 25 minute intervention
Self reported perception of heat using the the Thermal Sensation Scale.
Secondary Outcomes
- Conduit artery endothelial function(90 minutes after intervention)
- Lower Limb Microvascular Function(90 minutes after intervention)
- Exercise Capacity(90 minutes after intervention)