Gut Hormones After Oral Versus Intravenous Amino Acids

Not Applicable

Completed

• Conditions: Normal Non-fluency
• Interventions: Other: Oral amino acid mixture; Other: Intravenous amino acid administration

• Registration Number: NCT01366768
• Lead Sponsor: Lund University

Brief Summary

The study hypothesis is that gut hormones are released after oral but not intravenous amino acids which result in stimulation of insulin secretion.

Detailed Description

Amino acid mixture is given orally or intravenously to match total concentrations of amino acids in healthy subjects. Samples are taken regularly for 300 min after administrations. Plasma levels of the gut hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)and determined and related to plasma levels of insulin and glucagon.

Study Timeline

• Study Start: 2011-05
• Study First Submitted: 2011-05-31
• Study First Submitted QC: 2011-06-03
• Study First Posted: 2011-06-06
• Primary Completion: 2012-09
• Study Completion: 2012-09
• Status Verified: 2012-10
• Last Update Submitted: 2012-10-09
• Last Update Posted: 2012-10-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 12

Inclusion Criteria

• Healthy subjects

Exclusion Criteria

• Diabetes
• Liver disease
• Kidney disease
• Thyroid disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Oral amino acid mixture	Oral amino acid mixture	Oral administration of amino acid mixture in healthy volunteers
Intravenous amino acid administration	Intravenous amino acid administration	Intravenous infusion of amino acid mixture in healthy volunteers

Primary Outcome Measures

Name	Time	Method
Gut hormone secretion	300 min

Secondary Outcome Measures

Name	Time	Method
Insulin secretion	300 min

Trial Locations

Locations (1)

Department of Clinical Sciences Lund, Lund University; 🇸🇪 Lund, Sweden