Gut Hormones After Oral Versus Intravenous Amino Acids
Not Applicable
Completed
- Conditions
- Normal Non-fluency
- Registration Number
- NCT01366768
- Lead Sponsor
- Lund University
- Brief Summary
The study hypothesis is that gut hormones are released after oral but not intravenous amino acids which result in stimulation of insulin secretion.
- Detailed Description
Amino acid mixture is given orally or intravenously to match total concentrations of amino acids in healthy subjects. Samples are taken regularly for 300 min after administrations. Plasma levels of the gut hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)and determined and related to plasma levels of insulin and glucagon.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 12
Inclusion Criteria
- Healthy subjects
Exclusion Criteria
- Diabetes
- Liver disease
- Kidney disease
- Thyroid disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Gut hormone secretion 300 min
- Secondary Outcome Measures
Name Time Method Insulin secretion 300 min
Trial Locations
- Locations (1)
Department of Clinical Sciences Lund, Lund University
🇸🇪Lund, Sweden
Department of Clinical Sciences Lund, Lund University🇸🇪Lund, Sweden