Daily Protein Intake Distribution and MPS (ARCIII)

Not Applicable

Completed

• Conditions: Overweight
• Interventions: Other: whey protein; Other: placebo

• Registration Number: NCT02315014
• Lead Sponsor: Société des Produits Nestlé (SPN)

Brief Summary

To determine whether a balanced total daily dietary protein distribution supplemented with whey protein during a weight-loss intervention will result in increased muscle protein synthesis

Detailed Description

Not available

Study Timeline

• Study Start: 2013-03
• Primary Completion: 2013-06
• Study Completion: 2014-06
• Status Verified: 2014-11
• Study First Submitted: 2014-11-13
• Study First Submitted QC: 2014-12-10
• Last Update Submitted: 2014-12-10
• Study First Posted: 2014-12-11
• Last Update Posted: 2014-12-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 20

Inclusion Criteria

• Overweight/obese (BMI 27-40 kg/m2)
• Non-smokers
• Non-diabetic
• No history of hyperlipidemia
• Not taking medications thought to interfere with study
• Considered generally healthy

Exclusion Criteria

• Efforts to lose weight in previous 16 weeks
• Hyperlipidemia
• Blood pressure ≥ 140/90 mmHg
• Smoking
• Heart and other organ disease
• Type 2 diabetes
• Gastrointestinal disease
• Orthopedic injury interfering with exercise
• Use of certain medications (HRT, antihypertensives, diuretics, antiarythmia medications, antiresorptive agents, anabolic agents, hypoglycemic agents, and statins known to affect muscle i.e. Simvastatin and Zocor)

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
whey protein	whey protein	whey protein micelles
placebo	placebo	calorie-free placebo

Primary Outcome Measures

Name	Time	Method
muscle protein synthesis	up to 4 weeks	protein synthesis is evaluated in muscle biopsy tissue

Secondary Outcome Measures

Name	Time	Method
body composition is evaluated using DEXA	up to 4 weeks