NCT02315014已完成不适用
Effect of Balanced Daily Protein Distribution Supplemented With Whey Protein on Muscle Protein Synthesis in Overweight Older Men During Calorie Restriction and Exercise (ARC III)
Société des Produits Nestlé (SPN)0 个研究点目标入组 20 人开始时间: 2013年3月1日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 主要终点
- muscle protein synthesis
研究概览
简要总结
To determine whether a balanced total daily dietary protein distribution supplemented with whey protein during a weight-loss intervention will result in increased muscle protein synthesis
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- None
入排标准
- 年龄范围
- 60 Years 至 75 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Overweight/obese (BMI 27-40 kg/m2)
- •Non-smokers
- •Non-diabetic
- •No history of hyperlipidemia
- •Not taking medications thought to interfere with study
- •Considered generally healthy
排除标准
- •Efforts to lose weight in previous 16 weeks
- •Hyperlipidemia
- •Blood pressure ≥ 140/90 mmHg
- •Heart and other organ disease
- •Type 2 diabetes
- •Gastrointestinal disease
- •Orthopedic injury interfering with exercise
- •Use of certain medications (HRT, antihypertensives, diuretics, antiarythmia medications, antiresorptive agents, anabolic agents, hypoglycemic agents, and statins known to affect muscle i.e. Simvastatin and Zocor)
结局指标
主要结局
muscle protein synthesis
时间窗: up to 4 weeks
protein synthesis is evaluated in muscle biopsy tissue
次要结局
- body composition is evaluated using DEXA(up to 4 weeks)
研究者
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