Trigonella, Foeniculum, Chichorium in prevention of cancer-induced cachexia/anorexia
- Conditions
- Cancer-induced cachexia.Malignant neoplasm without specification of site
- Registration Number
- IRCT20180722040556N2
- Lead Sponsor
- Esfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
All adult patients (18 years and older) with advanced solid malignant tumour (Stage 3-4) who encountered cancer-induced anorexia or weight loss (equal or greater than 5% of the previous weight before cancer diagnosis or within the last two months). Cancer patients with serum creatinine < 2 mg /dl and serum total bilirubin < 2 mg /dl. Patients should not have any sign of dysphagia or gastrointestinal obstruction. The patients' life expectancy should be at least 3 months. Patients who are taking high doses of megestrol due to cachexia and anorexia simultaneously.
Patients who have undergone major surgery during the last 4 weeks.
Patients with a history of thrombophlebitis diseases.
Patients who have been taking systemic corticosteroid within the last 4 weeks or concurrently.
Patients who have cognitive impairment, psychiatric disorder or brain metastasis leading to cognitive impairment.
Patients who have diabetes, uncontrolled blood pressure or advanced heart failure (NYHA 4)
Patients who are alcoholic.
Patients who are pregnant or breast-feeding.
Patients with a known hypersensitivity reaction to one of the plants in study herbal combination.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cachexia/anorexia. Timepoint: Baseline and 8 weeks later. Method of measurement: Edmonton criteria.
- Secondary Outcome Measures
Name Time Method Quality of life. Timepoint: Baseline and eight weeks later. Method of measurement: Iranian Version of the EORTC QLQ.