Evaluation of the herbal combination of Cichorium inyubus, Trigonella foenum-graecum and Foeniculum vulgare in the prevention of cancer-induced cachexia/anorexia in solid tumours’ patients: a randomized, double-blinded, placebo-controlled clinical trial

Esfahan University of Medical Sciences0 个研究点目标入组 60 人开始时间: 待定最近更新: 2019年11月5日

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•All adult patients (18 years and older) with advanced solid malignant tumour (Stage 3-4) who encountered cancer-induced anorexia or weight loss (equal or greater than 5% of the previous weight before cancer diagnosis or within the last two months). Cancer patients with serum creatinine < 2 mg /dl and serum total bilirubin < 2 mg /dl. Patients should not have any sign of dysphagia or gastrointestinal obstruction. The patients' life expectancy should be at least 3 months. Patients who are taking high doses of megestrol due to cachexia and anorexia simultaneously.

•Patients who have undergone major surgery during the last 4 weeks.
•Patients with a history of thrombophlebitis diseases.
•Patients who have been taking systemic corticosteroid within the last 4 weeks or concurrently.
•Patients who have cognitive impairment, psychiatric disorder or brain metastasis leading to cognitive impairment.
•Patients who have diabetes, uncontrolled blood pressure or advanced heart failure (NYHA 4)
•Patients who are alcoholic.
•Patients who are pregnant or breast-feeding.
•Patients with a known hypersensitivity reaction to one of the plants in study herbal combination.

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