Sperm Capacitation Assay as a Tool to Predict Sperm Potential to Fertilize in IVF Treatment
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Sperm Capacitation
- Sponsor
- Assaf-Harofeh Medical Center
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Fertilization rate of human oocytes in thr "routine" IVF Laboratory work
- Last Updated
- 17 years ago
Overview
Brief Summary
Our aim is to evaluate the potential of a new laboratory method that measure sperm capacitation to predict fertilization of oocytes in patients that undergo IVF treatments
Detailed Description
Capacitation is a physiologic process in which the sperm acquire the potential to fertilize oocytes. Capacitation can be measured, but the available technics are expensive, inaccurate and complex. A new method to evaluate sperm capacitation was developed in Bar Ilan University, Israel. We intend to measure the capacitation of semen that is used for fertilizing human oocytes in patients treated at the IVF unit at Assaf Harofeh Medical Center.By this, to evaluate the potential of the new method to predict human oocyte fertilization.If the method will be found valuable, it will enable to develop new drugs/methods that may improve sperm capacitation and by this to improve oocyte fertilization leading to more embryos, pregnancies and deliveries.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients requiring IVF within the "routine" work of an IVF Unit
- •normo-responding woman
- •non ICSI cycles
Exclusion Criteria
- •Patients undergoing ICSI only cycle
- •Low responders-less than 8 oocytes
- •Male patients with low semen volume
Outcomes
Primary Outcomes
Fertilization rate of human oocytes in thr "routine" IVF Laboratory work
Time Frame: One year