The effectiveness of Ultrasound-guided three-needle approach of genicular nerve block in improving pain, functionality and quality of life in patients suffering from chronic knee osteoarthritis: A prospective observational study
Trial Snapshot
- Phase
- Phase 4
- Status
- Not yet recruiting
- Sponsor
- AIIMS Kalyani
- Enrollment
- 42
- Locations
- 1
- Primary Endpoint
- Visual Analog Scale
Study Overview
Brief Summary
Osteoarthritis (OA) of the knee joint is one of the common joint degenerative diseases affecting almost 12 % of the population over their sixties. Approximately 70-80% of the affected individuals are sixty-five or older. Knee OA is a chronic joint disease leading to pain, disability and hamper daily activities of the patients, which ultimately leads to significant social impairments and healthcare burden worldwide.
Both non-surgical and surgical methods are available for the management of OA knees. In non-surgical options, we have patient education, lifestyle modification, physical therapies, bracing, and pharmacological management. Different types of injections like intra-articular steroid, prolotherapy, Ozone, platelet-rich plasma (PRP), hyaluronic acid are also available. A few recent interventions are stem cell therapy, genicular nerve block; all of which are aimed to reduce the symptoms, improve the functionality of the affected individuals. In severe cases, only surgical management is the remaining option, i.e. partial or total knee arthroplasty.
In case of severe OA knee, Kellgren-Lawrence grade 4 surgery is required. The majority of the interventions are rendered ineffective in severe OA knee. Therefore, this study aims to evaluate the effectiveness of genicular nerve block in cases of severe OA kneeWe hypothesized that there would be improvement in cases of severe OA knee in the domains of pain and functionality.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Masking
- None
Eligibility Criteria
- Ages
- 45.00 Year(s) to 70.00 Year(s) (—)
- Sex
- All
Inclusion Criteria
- •Clinically diagnosed case of osteoarthritis knee according to American college of rheumatology criteria (ACR) 2.Radiographic Kellgren-Lawrence grade 3 and 4 3.Knee pain with pain intensity of more or equal to 4 of 10 in visual analog scale, most of the days for last three months , refractory to conservative management.
Exclusion Criteria
- •Severe neurological or psychiatric diseases
- •History of any steroid injection within 3 months
- •Previous knee surgeries (unicompartmental or total arthroplasty, debridement arthroscopy, osteotomies)
- •Persons using anticoagulants or with bleeding disorders
- •Persons with uncontrolled diabetes and hypertension
- •Any history of allergy, or superficial skin infection.
Outcomes
Primary Outcomes
Visual Analog Scale
Time Frame: Baseline , after 2 weeks, after 4 weeks, after 8 weeks and after 4 months
Secondary Outcomes
- Western Ontario and McMaster Universities(2 weeks, 4 weeks, 8 weeks and 4 months)
- Knee injury and osteoarthritis outcome score(2 weeks, 4 weeks, 8 weeks and 4 months)
Investigators
Lt Col Dr Mohit Kataruka
AIIMS, Kalyani