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Glutamine and Traumatic Brain Injury

Early Phase 1
Not yet recruiting
Conditions
Brain Injuries, Traumatic
Interventions
Other: Placcebo
Drug: Glutamine
Registration Number
NCT05569993
Lead Sponsor
Assiut University
Brief Summary

Glutamate is an important neurotransmitter present in over 90% of all brain synapses and is a naturally occurring molecule that nerve cells use to send signals to other cells in the central nervous system.

Glutamate is a non-essential amino acid with restricted passage to the brain from the blood. In the CNS, glutamate is synthesised in neurons as part of the glutamate-glutamine cycle.5,6 so it plays an essential role in normal brain functioning and can improve situations related to impaired cognitive,motor and emotional functions and can be used to improve traumatic brain injury patient general health status

Detailed Description

The term "brain injury" covers a wide range of conditions and injuries relating to the brain, skull, and scalp. A traumatic brain injury (TBI) usually results when the head or body suffers from a violent blow or jolt that results in swelling, bruising, bleeding, or tearing of the brain tissue which any damage to it has the potential to change the way your body operates.

Now ,(TBI) is considered one of the major causes of disability and deaths ,As It contributes more than 30% Of deaths worldwide . Those who survive a TBI can face effects that last a few days, or the rest of their lives. Effects of TBI can include impaired motor, cognitive and emotional functioning. These issues not only affect individuals but can have lasting effects on families and communities.TBI can also cause some inflammatory mediators to be released in circulation that affect brain and systemic organs such as cortisol,IL6 and TNF etc. A lot of modialities have been introduced to help in decreasing these side effects.

Glutamine,a non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from glutamic acid and ammonia. It is the principal carrier of nitrogen in the body and is an important energy source for many cells.glutamine has a restricted passage to the brain from blood but it is synthesised in the brain as a part of the glutamate-glutamine cycle.5,6 so it present in over 90% of all brain synapses and is a naturally occurring molecule that nerve cells use to send signals to other cells in the central nervous system,maintaining normal brain function and can improve situations related to impaired cognitive,motor and emotional functions.

Hypothesis of this study; Does glutamine therapy have a positive effect on traumatic brain injury patients ?

Recruitment & Eligibility

Status
NOT_YET_RECRUITING
Sex
All
Target Recruitment
60
Inclusion Criteria
  • 18 to 60 years old
  • mild to moderate head trauma
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Exclusion Criteria
  • patients with concurrent cns dysfunction
  • Renal failure patient
  • diabetic patients with neuropathy
Read More

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
Placcebo groupPlaccebo30 patients will recieve placcebo for first 7 days in ICU
Glutamine groupGlutamine30 patients will recieve .3 mg/kg of glutamine for first 7 days in ICU
Primary Outcome Measures
NameTimeMethod
The duration of ICU stayFirst 30 days

The duration of ICU stay after glutamine adiminstration

Secondary Outcome Measures
NameTimeMethod
The incidence of Convulsions30 days

Convulsions controled by glutamine

Consiousness level by Glagow coma scale30 days

Glasgow coma scale improvement

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