The effect of cold acclimation on human brown adipose tissue and skeletal muscle mitochondrial uncoupling -a comparison in obesity and type 2 diabetes - Cold acclimation and brown fat - comparison in obesity and type 2 diabetes

niversiteit Maastricht0 个研究点目标入组 21 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

Trial ended prematurely

•* Caucasians
•o Obese without type 2 diabetes: 18-65 years
•o Obese with type 2 diabetes: 18-65 years
•* BMI: 28-35 kg/m2
•* Fat percentage: > 23%
•* Gender: Male
•* Specifically for obese subjects with type 2 diabetics:
•o Diagnosed with type 2 diabetes at least 1.5 years before the start of the study
•o Well-controlled type 2 diabetes: HBA1C < 8.5%
•o Oral glucose lowering medication (metformin only or in combination with sulfonylurea agents)
•o No signs of active diabetes-related co-morbidities like cardiovascular diseases, diabetic foot, polyneuropathy, retinopathy.
•o No signs of active uncontrolled hypertension, liver of kidney malfunction
•* Specifically for obese subjects without type 2 diabetes:
•o Fasting blood glucose level <6.1 mmol/l
•o No signs of active cardiovascular disease, uncontrolled hypertension, liver of kidney malfunction.

•* Participate in physical activity more than 2x/week
•* Participation in earlier research that included a PET/CT-scan
•* Radiation therapy due to medical treatment
•* Unstable body weight (weight gain or loss > 5 kg in the last three months)
•* Participation in another biomedical study within 1 month before the first screening visit;* Specifically for obese subjects without type 2 diabetes:
•o Elevated fasting blood glucose level (> 6.1 mmol/L);* Specifically for obese subjects with type 2 diabetes:
•o Impaired kidney- and/or hepatic function
•o Diabetes related co-morbidities like cardiovascular diseases, diabetic foot, polyneuropathy, and retinopathy.
•o Insulin dependent diabetic subjects

发起方