The effect of using mannitol serum in Cardiopulmonary Bypass Priming on Laboratory Parameters and Delirium in patients undergoing Coronary Artery Bypass graft surgery

Phase 3

Recruiting

Conditions: Complications caused by the use of cardiopulmonary bypass in patients undergoing coronary bypass surgery.
Atherosclerotic heart disease of native coronary artery
I25.1

Registration Number: IRCT20221129056660N1

Lead Sponsor: Oroumia University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 90

Inclusion Criteria

Age between 18-70 years old
Absence of liver failure in the form of (AST) > 40 unit/L and (ALT) > 40 unit/L
No history of heart surgery
Absence of serum creatinine above 1.5 mg/dL and patients who had acute kidney failure during the last 5 days due to receiving medication before surgery.
Absence of severe carotid stenosis in both carotids or one of the carotids
No emergency surgery
Absence of infective endocarditis
Absence of left ventricular ejection fraction less than 30% and patients with severe right ventricular failure
Lack of hemoglobin level less than 10
Lack of body mass index more than 40
Absence of malignant and benign blood cancers
Failure to test impaired pulmonary function before surgery, FEV1 <65%
No history of mental illness
Median sternotomy patients undergoing routine CABG
Absence of arrhythmia before operation

Exclusion Criteria

Use of hemofilter
Retrograde autologous prime before starting cardiopulmonary bypass
Receiving Ringer's serum more than 1000 ml during cardiopulmonary bypass
Receiving starch serum during and after the operation
Using Bertschneider's cardioplegia to induce cardiac arrest
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Instability of vital signs during surgery
Performing additional surgery such as heart valve surgery during CABG surgery
Use of ECMO and intra-aortic balloon pump before and after surgery
Aortic clamp more than 120 minutes and pump time more than 150 minutes
Use of non-invasive mechanical ventilation after surgery
Redo-surgery
Electrolyte imbalance

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The average score of cardiac enzymes (CPK, CK-MB, Troponin C). Timepoint: 30 minutes, 24 and 48 hours after surgery. Method of measurement: Venous blood sample, center laboratory.;Average of creatinine and BUN. Timepoint: 30 minutes, 24 and 48 hours after surgery. Method of measurement: Venous blood sample, center laboratory.;Duration of mechanical ventilation, intensive care unit and hospital stay. Timepoint: Until discharge. Method of measurement: Based on hours and days.;Amount of diuresis. Timepoint: During, 24 and 48 hours after surgery. Method of measurement: milliliter.;In-hospital mortality rate. Timepoint: During discharge or death. Method of measurement: Patient's medical record.;The incidence of delirium. Timepoint: Every shift in the intensive care unit. Method of measurement: Delirium Observation Screening Scale(DOSS).

Secondary Outcome Measures