Comparative study between efficacy of 18 percent Salicylic acid and 15 percent Azelaic acid combination peel vs 20 percent Salicylic acid and 10 percent Mandelic acid combination peel in Acne vulgaris grade II & III - A Randomized Controlled Trial

One of the most common illnesses affecting adolescents is acne vulgaris. It causes discomfort on a physical and psychological level and is typified by the development of lesions with or without pigmentation and scarring, usually over the face but occasionally over the trunk. Different oral and topical drugs, as well as techniques including chemical peeling and microneedling, are used to treat it. One safe and efficient way to treat this issue is chemical peeling.

In this randomised controlled experiment, the effectiveness of two different peeling techniques—Group 1 using a combination of 18% salicylic acid and 15% azelaic acid and Group 2 using a combination of 20% salicylic acid and 10% mandelic acid—in treating Acne vulgaris grades II and III is being compared. On the initial visit, which will serve as the baseline, the participants will be rated in accordance with the Indian Acne Alliance (IAA) grading system. Following then, they will be checked on every two weeks for a maximum of six sittings, or until they attain grade I, whichever comes first, with each visit involving grading. The significance difference for comparison groups at the 5% level (P<=0.05) will be determined using the T-test. The active control group consisted of salicylic acid plus azelaic acid combination peel, while the experimental group consisted of salicylic acid plus mandelic acid combination peel. The IAA grade of acne, which is a categorical variable, will be evaluated using the Fisher exact test to determine the significance of the correlation at various risk variables. Multivariate analysis will be used to examine all confounding variables.

The Scientific Scrutiny/Institutional Research Committee and the Institutional Ethics Committee (IEC) have both approved. Every participant will be required to provide written, informed consent, and both during and after the study, the privacy of their personal data will be guaranteed.