Intravitreal Decorin Preventing Proliferative Vitreoretinopathy in Perforating Injuries: a Pilot Study.

This is prospective, single-center, open-label, interventional case series. Twelve patients with open globe injuries presenting to the causality department at Kasr Al Ainy Teaching Hospital, Cairo University, were enrolled in our study. Those patients were assigned to Ocular Trauma Score category 1 or 2 in which the visual prognosis after treatment is poor (Category 1 prognosis: 74% no light perception, 15% light perception to hand movements, Category 2 prognosis: 27% no light perception, 26% light perception to hand movements) (31).

An informed consent was obtained from the participant prior to the conduct of any study procedure. The participant was adequately informed about the study, understood risks, benefits and alternative treatments, and voluntarily agreed to participate in the study. He / She was given ample time to consider participation and had his / her questions addressed in a satisfactory manner before agreeing to participate and signing the informed consent form. Participants were free to choose to withdraw from the study at any time without any responsibility, even if the study has not been completed.

Pre-operative Evaluation: 1. Baseline systemic examination: including clinical evaluation, complete blood picture, liver function tests and kidney function tests. 2. Full ocular examination: All patients were subjected to complete ophthalmological examination including: Best corrected visual acuity (according to the Snellen VA chart). Slit lamp examination. 3. CT scan (Sytec and BrightSpeed; GE Healthcare, Milwaukee, Wis): Unenhanced CT of the orbits was performed; axial, coronal and sagittal views with contiguous 2-mm-thick sections.

4. Full Field ERG using a full field flash Ganzfeld stimulator (Roland Consult, Electrophysiologic Diagnostic Systems, Wiesbaden, Germany): The ISCEV-ERG GF program was used to record standard ERGs. All responses were differentially amplified, displayed on an oscilloscope, digitized and stored on a compact disc. An adjustable voltage window was used to reject records contaminated by artifacts.

Dark adapted ERG responses were obtained after a minimum of 30 minutes of dark adaptation and included an isolated rod, standard flash (maximal) response, and oscillatory potentials. Light adapted responses included a single white flash and 30-Hz flicker. ERG amplitudes and implicit time values were measured according to recommendations by the International Society for Clinical Electrophysiology of Vision.