Comparison of Morphological and Radiological Data in Patients With Urolithiasis

Not Applicable

• Conditions: Urolithiasis
• Interventions: Procedure: Percutaneous Nephrolithotomy; Procedure: Partial nephrectomy; Procedure: Radical nephrectomy

• Registration Number: NCT04506723
• Lead Sponsor: I.M. Sechenov First Moscow State Medical University

Brief Summary

The aim of the study was to compare the ultrastructural changes in the renal parenchyma with the results of postprocessing CT analysis with contrast enhancement in patients with urolithiasis.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-04-30
• Study First Submitted: 2020-08-06
• Study First Submitted QC: 2020-08-06
• Study First Posted: 2020-08-10
• Status Verified: 2021-07
• Last Update Submitted: 2021-07-21
• Last Update Posted: 2021-07-22
• Primary Completion: 2021-12-31
• Study Completion: 2021-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Patients with urolithiasis	Percutaneous Nephrolithotomy	Patients with confirmed urolithiasis who is assigned to PCNL.
Patients without urolithiasis	Partial nephrectomy	Patients with renal tumor without urolithiasis in history who is assigned to partial or radical nephrectomy due to renal tumor.
Patients without urolithiasis	Radical nephrectomy	Patients with renal tumor without urolithiasis in history who is assigned to partial or radical nephrectomy due to renal tumor.

Primary Outcome Measures

Name	Time	Method
To evaluate the features of interrenal transport of contrast agent and the structural state of the renal tissue	1 month	The data of 3D analysis of CT of the kidneys in patients with urolithiasis

Secondary Outcome Measures

Name	Time	Method
To assess the features of the morphological structure of glomeruli, tubules, perivascular and interstitial spaces of renal tissue in patients with urolithiasis	2 weeks	The assessment will be based on intraoperative biopsy

Trial Locations

Locations (1)

Institute for Urology and Reproductive Health, Sechenov University.; 🇷🇺 Moscow, Russian Federation