Pre-operative Chemotherapy and Radiation Therapy for Esophageal Carcinoma
Phase 2
Completed
- Conditions
- Esophageal Cancer
- Registration Number
- NCT00230451
- Lead Sponsor
- University of Michigan Rogel Cancer Center
- Brief Summary
Surgery (esophagectomy or removal of the esophagus)has been the standard treatment for cancer of the esophagus. However, evidence suggests that preoperative chemotherapy and radiation therapy may add benefit. The purpose of this study is to determine if a treatment program of combined chemotherapy and radiation therapy prior to surgery and chemotherapy after surgery will delay or eliminate recurrence of the cancer.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
Not provided
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Exclusion Criteria
- Patients with active infection, pregnancy, lactating females, serious inter-current medical conditions including congestive heart failure, cardiac arrhythmias, or symptomatic coronary artery diseases are ineligible.
- No prior treatment allowed. No prior thoracic radiation.
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Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method To determine the rate of complete histologic response induced by this neoadjuvant chemotherapy and radiation therapy regimen.
- Secondary Outcome Measures
Name Time Method To assess the qualitative and quantitative toxicities of this regimen. To determine the overall survival and time to relapse in patients treated with preoperative chemotherapy and radiation therapy followed by adjuvant combination chemotherapy.
Trial Locations
- Locations (1)
University of Michigan Cancer Center
🇺🇸Ann Arbor, Michigan, United States