A Phase II Trial of Preoperative Chemotherapy and Radiation Therapy Followed by Adjuvant Combination Chemotherapy for Patients With Loco-Regional Esophageal Carcinoma

University of Michigan Rogel Cancer Center2 个研究点分布在 1 个国家开始时间: 1997年11月最近更新: 2010年1月15日

适应症

试验速览

阶段: 2 期
状态: 已完成
发起方: University of Michigan Rogel Cancer Center
试验地点: 2
主要终点: To determine the rate of complete histologic response induced by this neoadjuvant chemotherapy and radiation therapy regimen.

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

Surgery (esophagectomy or removal of the esophagus)has been the standard treatment for cancer of the esophagus. However, evidence suggests that preoperative chemotherapy and radiation therapy may add benefit. The purpose of this study is to determine if a treatment program of combined chemotherapy and radiation therapy prior to surgery and chemotherapy after surgery will delay or eliminate recurrence of the cancer.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Single Group
主要目的: Treatment
盲法: None

入排标准

年龄范围: 18 Years 至 75 Years（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

未提供

排除标准

•Patients with active infection, pregnancy, lactating females, serious inter-current medical conditions including congestive heart failure, cardiac arrhythmias, or symptomatic coronary artery diseases are ineligible.
•No prior treatment allowed. No prior thoracic radiation.

结局指标

主要结局

To determine the rate of complete histologic response induced by this neoadjuvant chemotherapy and radiation therapy regimen.

次要结局

To assess the qualitative and quantitative toxicities of this regimen.
To determine the overall survival and time to relapse in patients treated with preoperative chemotherapy and radiation therapy followed by adjuvant combination chemotherapy.

研究者

发起方

University of Michigan Rogel Cancer Center

申办方类型

Other

研究点 (2)

Loading locations...

相似试验

Unknown

2 期

Neoadjuvant Chemotherapy With Nab-paclitaxel Plus Cisplatin and Capecitabine for Locally Advanced Thoracic Esophageal Squamous Cell CarcinomaEsophageal Squamous Cell Carcinoma

NCT04390958Chinese Academy of Medical Sciences70

已完成

2 期

Combination of Toripalimab and Chemoradiotherapy in Esophageal CancerUnresectable Esophageal Cancer

NCT04005170Mian XI42

Unknown

2 期

Neoadjuvant Chemoradiotherapy Combined With Perioperative Toripalimab in Locally Advanced Esophageal CancerAdvanced Esophageal Squamous Cell Cancer

NCT04437212RenJi Hospital20

已完成

2 期

Preoperative Chemoradiotherapy and MK-3475 for Esophageal Squamous Cell Carcinoma (ACTS-29)Esophageal Squamous Cell Carcinoma

NCT02844075Yonsei University28

已完成

2 期

Chemoradiation and Tetrathiomolybdate (TM) in Patients With Esophageal CarcinomaEsophageal Carcinoma

NCT00176800University of Michigan Rogel Cancer Center69