Preoperative Microvascular Protection in Patients Undergoing Major Abdominal Surgery

Phase 4

Completed

• Conditions: Glycocalyx degradation; Endothelial dysfunction; Abdominal Surgery; Cardiovascular - Diseases of the vasculature and circulation including the lymphatic system; Surgery - Other surgery; Anaesthesiology - Other anaesthesiology

• Registration Number: ACTRN12618000361202
• Lead Sponsor: Austin Health

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-03-09
• Study Completion: 2020-02-14
• Last Update Posted: 17 August 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 72

Inclusion Criteria

•Adults aged > 18 years
•Undergoing elective open bowel resection, pancreatic resection or liver resection surgery
•Requiring a hospital stay of at least one postoperative night
•Routine use of arterial line for continuous blood pressure monitoring and intermittent positive pressure ventilation via an endotracheal tube as part of standard anaesthesia care
•American Society of Anesthesiologists (ASA) Physical status <5

Exclusion Criteria

•Poorly controlled diabetes (HbA1c > 9.0% or HbA1c >75 mmol/mol) if known
•Allergy to albumin or dexamethasone
•Surgery is being performed for treatment of an infective process (e.g. intra-abdominal sepsis)
•Planned postoperative intubation or ventilation
•Concurrent immunosuppressive therapies or immunosuppressed state
•Chronic steroid use (prednisolone 10mg/day or equivalent for greater for >1 week in preceding 3 months)
•Pregnant or lactating woman
•Surgical procedures within the preceding 2 months or expected within the subsequent 30 days

Study & Design

• Study Type: Interventional
• Study Design: Not specified