In preterm infants with bronchopulmonary dysplasia (BPD) would alterations in inspired oxygen concentrations induce changes that would allow chemoreceptor reflex activity and VQ mismatch to be measured

The Ritchie Centre, Monash University0 sites24 target enrollmentFebruary 1, 2013

Overview

No summary available.

Registry

who.int

Start Date

February 1, 2013

End Date

TBD

Last Updated

6 years ago

Study Type

Interventional

Sex

All

Sponsor

The Ritchie Centre, Monash University

•Preterm infants \< 29 weeks gestation.
•1\. Healthy preterm infant (\<29 weeks) without BPD
•Infants with BPD defined as need for oxygen or respiratory support at 36 weeks completed postmenstrual age (PMA).
•Infants will be further subdivided into
•2\. Mild BPD (no need for oxygen or respiratory support at 36 weeks PMA but need for either at 28 days of age).
•3\. Moderate BPD \- need for supplemental oxygen (\<30%) at 36 weeks PMA butself\-ventilating
•4\. Severe BPD \- need for supplemental oxygen (\>30%) at 36 weeks PMA or needing respiratory support.
•Infants in Group 1, the healthy preterm infant will be the control group while infants in Groups 2 to 4 with mild/moderate/severe BPD will be in the intervention group