Beta2-adrenergic System and Training

Not Applicable

• Conditions: Healthy
• Interventions: Behavioral: Training; Drug: Formoterol; Drug: Placebo

• Registration Number: NCT04616261
• Lead Sponsor: University of Copenhagen

Brief Summary

This project aims to examine the trainability of the beta2-adrenergic system with respect to the individual performance response

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-10-29
• Status Verified: 2020-11
• Study First Submitted QC: 2020-11-03
• Last Update Submitted: 2020-11-03
• Study First Posted: 2020-11-04
• Last Update Posted: 2020-11-04
• Study Start: 2020-11-10
• Primary Completion: 2022-11-10
• Study Completion: 2022-11-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Male
• Target Recruitment: 30

Inclusion Criteria

• 18 to 45 years of age
• Trained individuals with a maximal oxygen uptake above 55 ml/min/kg
• Body mass index lower than 26

Exclusion Criteria

• Allergy towards study drug
• Unacceptable side effects to the study drug
• Chronic disease deemed by the MD to interfere with the study
• Smoking
• Use of prescription medicine

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Arm && Interventions

Group	Intervention	Description
SET-HIGH	Training	High volume speed endurance training
SET-HIGH	Formoterol	High volume speed endurance training
SET-HIGH	Placebo	High volume speed endurance training
SET-LOW	Training	Low volume speed endurance training
SET-LOW	Formoterol	Low volume speed endurance training
SET-LOW	Placebo	Low volume speed endurance training

Primary Outcome Measures

Name	Time	Method
Sprint performance	½ hour after administration of formoterol or placebo	Change in power output during maximal cycling in response to formoterol

Secondary Outcome Measures

Name	Time	Method
Cycling endurance performance	½ hour after administration of formoterol or placebo	Change in 4-min time trial performance in response to formoterol