Efficacy of Rosuvastatin on improvement of fetal growth restrictio

Phase 3

Recruiting

Conditions: Intrauterine growth restriction.
Maternal care for known or suspected poor fetal growth
O36.5

Registration Number: IRCT20140317017035N8

Lead Sponsor: Shiraz University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Female

Target Recruitment: 88

Inclusion Criteria

singleton pregnancy
Gestational age between 20 and 34 weeks
The estimated gestational weight by ultrasound should be less than 3 percentile
The estimated gestational weight by ultrasound is less than 10th percentile, which is associated with abnormal Doppler sonography
Informed consent

Exclusion Criteria

Preeclampsia at the time of diagnosis
Chromosomal disorder and anomaly
Statin intolerance or allergy
Acute pulmonary edema
Liver disorder
High blood pressure despite treatment
Hellp syndrome
Severe neurological symptoms
Ductus venosus a- wave reversa

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The duration of pregnancy: the interval between the diagnosis of the disorder and the termination of pregnancy. Timepoint: From the time of starting the drug until the end of pregnancy. Method of measurement: Calculate the number of days.;Umbilical artery Doppler. Timepoint: Doppler ultrasound examination at the beginning of the study and then weekly until the end of the delivery. Method of measurement: Ultrasound.;Middle cerebral artery Doppler. Timepoint: Doppler ultrasound examination at the beginning of the study and then weekly until the end of the delivery. Method of measurement: Ultrasound.

Secondary Outcome Measures

Name	Time	Method
Birth weight. Timepoint: Birth. Method of measurement: scales.;Duration of hospitalization of the fetus in the neonatal intensive care unit. Timepoint: Discharge time from NICU. Method of measurement: number of days.;Apgar one and five minutes after the birth of the fetus. Timepoint: The first minute of birth and 5 minutes after birth. Method of measurement: special form.