Real-time tumor-tracking proton beam therapy for liver cancer - Real-time tumor-tracking proton beam therapy for liver cancer

Department of Radiation Medicine, Hokkaido University Graduate School of Medicine0 个研究点目标入组 24 人开始时间: 2015年2月26日最近更新: 2023年10月17日

适应症

试验速览

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•1)With active infections in the irradiated sites 2)With active other cancers 3)With severe uncontrolled diabetes 4)With severe renal failure which needed dialysis 5)With severe heart disease, or some serious complications, i.e., SLE, Scleroderma, interstitial pneumonia 6)With an inflammatory bowel syndrome, i.e., Crohn's disease, ulcerative colitis 7)Previous abdominal irradiation 8)Previous treatment for the tumor within 30 days 9)With ascites of grade 2 or higher (CTCAE ver4.03) 10)Hepatic function characterized by a Child-Pugh score 10 or over 11)Extrahepatic metastasis 12)Multicentric HCCs, except for those with the following two conditions: (1) multinodular aggregating HCC that could be encompassed by single clinical target volume; (2) lesions other than targeted tumor that were judged as controlled with prior surgery and/or local ablation therapy. 13)Maximum tumor diameter on CT and/or MRI over 10 cm 14)Tumor within 2 cm of the gastrointestinal tract 15)Total occlusion of the main trunk and/or major branches of the portal vein (the main left and right portal veins) by tumor thrombus. 16)With implantable cardioverter defibrillator or permanent pacemaker 17)Pregnancy 18)Considered that participation in this trial is difficult because of psychiatric symptoms or psychosis 19)Cannot be held rest for about 30 minutes 20)Weight over 135 kg 21)Cannot be implanted Au marker in the lung 22)Allergic to radiation 23)Unsuitable for enrollment judged by principal investigator

发起方

Department of Radiation Medicine, Hokkaido University Graduate School of Medicine