Cerebral Microembolism in the Critically Ill With Acute Kidney Injury

Not Applicable

Terminated

• Conditions: Cerebral Embolism
• Interventions: Device: Renal replacement therapy

• Registration Number: NCT02621749
• Lead Sponsor: Insel Gruppe AG, University Hospital Bern

Brief Summary

The primary objective of this study is to investigate the impact of continuous renal replacement therapy and intermittent renal replacement therapy on microbubble / cerebral microemboli generation in a cohort of critically ill patients with dialysis-dependent acute kidney injury.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2015-11-20
• Study First Submitted QC: 2015-12-01
• Study First Posted: 2015-12-03
• Study Start: 2017-01
• Status Verified: 2022-11
• Primary Completion: 2022-11-06
• Study Completion: 2022-11-06
• Last Update Submitted: 2022-11-07
• Last Update Posted: 2022-11-14

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 66

Inclusion Criteria

• > 18 yrs.
• Signed IC

Exclusion Criteria

• Heart disease (PFO, ASD, VSD, severe valvular disease)
• Atrial fibrillation
• Cerebrovascular pathology
• Missing temporal bone window
• Allergy to plastic contained in the investigative device (transcranial Doppler)
• Chronic kidney disease
• Pregnancy
• Participation in another study

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
IRRT group	Renal replacement therapy	the IRRT group receives intermittent renal replacement therapy after termination of CRRT.
CRRT group	Renal replacement therapy	the CRRT group receives continuous renal replacement therapy for acute kidney injury

Primary Outcome Measures

Name	Time	Method
Cerebral Microembolic Load detected by Transcranial Doppler Ultrasound	During hemodialysis therapy

Trial Locations

Locations (1)

University Hospital Bern; 🇨🇭 Bern, Switzerland