Comparison of effectiveness of topical metformin 30 percent gel vs topical benzoyl peroxide 2.5 percent gel alone in acne vulgaris a randomized non inferiority open label study

The patients meeting all the inclusion criteria and not meeting any exclusion criteria shall be considered to participate in the study

A detailed history including the duration of disease, associated medical conditions, treatment history and family history is to be taken

The patients are randomized according to random number generator and allocated to two interventional group

Assessor shall be blinded

Two medications shall be given

One group will be given topical metformin 30% gel once daily application at night for 8 weeks

The other group will be given topical benzoyl peroxide 2.5% gel once daily application at night in acne for 8 weeks

Acne lesions were counted and documented according to type (comedones, papules, pustules, nodules) at the first visit and every follow up

Follow up is done at baseline, 4th, 8th, 12th and 16th week

Clinical photographic assessment and quantitative assessment by counting the number of facial inflammatory lesions will be done at every 4 weeks till 16 weeks

Global assessment of improvement should be done by the investigator at each visit, according to the following criteria - excellent for greater thant 75% improvement, good for about 50% improvement, fair for about 25% improvement and poor for little or no improvement

Any patient developing side effects shall be pulled out of intervention