ISRCTN29665463已完成不适用
A placebo-controlled trial of anti-TNFa chimeric monoclonal antibody (infliximab, remicade) in the modification of vascular disease markers in active rheumatoid arthritis
Guy's & St Thomas' NHS Foundation Trust (UK)0 个研究点目标入组 30 人开始时间: 2007年11月23日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. RA defined by American College of Rheumatology criteria
- •2. Referred for TNF-blocking therapy according to the British Society of Rheumatology (BSR) criteria
- •3. Patients giving written informed consent
- •4. Patients failed two DMARDs including methotrexate
- •5. Disease Activity Score 28 (DAS 28) greater than 5.1 on two occasions four weeks apart
- •6. Patients taking methotrexate (<=25 mg/week)
排除标准
- •1. Age <18 years
- •2. History of ischemic heart disease, cerebrovascular disease, peripheral vascular disease, diabetes mellitus
- •3. Previous treatment with infliximab or any therapeutic agent targeted at reducing TNFa
- •4. Treatment with aspirin
- •5. Patients with evidence of current or previous infection with tuberculosis (TB)
研究者
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