Comparison of intubating conditions and hemodynamic effects between Rocuronium and Cisatracurium in patients undergoing off pump coronary artery bypass graft surgery :A randomized double blinded study
试验速览
- 阶段
- 2/3 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 140
- 试验地点
- 1
- 主要终点
- Onset of action
研究概览
简要总结
Neuro muscular blockers are very important adjuvant to general anaesthesia. They aid in Endotracheal intubation, Mechanical ventilation, reduce anaesthetic requirements ,facilitate surgery for long hours and decrease oxygen consumption. An ideal neuromuscular blocking agent should have rapid onset of action ,produce good intubating condition rapidly ,intermediate to short duration of action ,provide rapid airway control. In the development of new neuro muscular blocking agents, the anaesthesiologist is now provided with drugs that are almost free of unwanted side effects, have a time course of action that allows great control of their activity and in most cases, allows the anaesthesiologist to substitute then for succinylcholine.
In selecting a neuro muscular blocking agent, an anaesthetist stives to achieve three competing goals :
-
Rapid adequate muscle relaxation
-
Hemodynamic stability
-
Predictable complete return of skeletal muscle function
In this study comparision between Rocuronium and Cisatracurium hemodynamic effects and rapid onset of action .
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 35.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •American society of Anaesthesiologist(ASA) status 3.
排除标准
- •Patient refusal Inability to give consent to the study Coagulopathy, sepsis, hepatic or renal failure Allergic to Local Anaesthetic drugs Pre existing neuromuscular disorder Pregnant female Ejection fraction less than 40% ASA -4 and above.
结局指标
主要结局
Onset of action
时间窗: Heart rate-baseline,at 1 minute,3 minute, 5 minute
Hemodynamic effects of Heart rate after tracheal intubation between two groups
时间窗: Heart rate-baseline,at 1 minute,3 minute, 5 minute
次要结局
- Interpretation of TOF count for the onset of action(Baseline)
研究者
DrSivalakshmi
SRI RAMACHANDRA MEDICAL COLLEGE AND RESEARCH HOSPITAL