Efficacy of Rewandchini with Asl as Zimad in Kalaf (Melasma) - A Randomized Controlled Trial.

Melasma is common hypermelanosis that typically occurs on sun-exposedareas in the face. The overall prevalence of Melasma in women varies bygeography and population between 1.5% and 33.3%. The estimated prevalenceof melasma in pregnant women is up to 70%. The prevalence of melasma in men assuggested in one simple survey is approximately 20%. It is a cosmeticissue that sometimes cause great psychological suffering. As per one study,which showed that melasma associated with significant impact on health-relatedquality of life. It is characterized by sharply demarcated, blotchy, brownmaculae, usually symmetrical on the cheeks, forehead, sometimes on the upperlip and neck. According to Unani system factors affecting kalaf  includesfrequent exposure to excess abnormal external heat;  Dam-e-Muharraq (charredblood), Sauda-e-Muharraq (charred melancholic blood),  Ghiza-e-Kaseef (indigestiblefood), constant local pressure, pregnancy, liver disease i.e. Du’fal-kabid (liver atony) and Sughàr al-kabid. Although Melasma isasymptomatic it is disfiguring skin disease that has a negative impact on lifeand the self-esteem of effected individuals and causes distress in the patientsas it mainly affects the face. It affects their psychological andemotional wellbeing and often feel bothered, frustrated, embarrassed, anddepressed about their skin appearance.

The physician described various regimenal and pharmacotherapies for themanagement of Melasma in detail. The Pharmacological action of zimad inpresent study exhibits: Jali (detergent), qabiz (astringent), Qasir (Scaling), Ghassal (irrigator), Mubassir (vesicant), Muhammir (rubifecient), Raade-Mawaad (divergent), Mughazzi (nutrient), muhalil-e-awram (anti-inflammatory),antioxidant, antimicrobial, dafa-e-quba (antifungal), mana-e-sartan (anticancer), mana-e-qurooh (antiulcer)properties.

Therefore a clinical trial entitled ’Efficacy of Rewandchini with Asl as Zimad in Kalaf (Melasma)- A Randomized controlled trial’ is contemplated to evaluate the efficacyof rewandchini with Asl with the objective of improvement in skin lesions andto improve the quality of life of the sufferers of Melasma.