Intraperitoneal Chemotherapy in Recurrent Ovarian Cancer
Not yet recruiting
- Conditions
- Intravenous Chemotherapy Versus Intraperitoneal Chemotherapy in Recurrent Ovarian Cancer
- Interventions
- Drug: Chemotherapy
- Registration Number
- NCT06535334
- Lead Sponsor
- Far Eastern Memorial Hospital
- Brief Summary
This study aims to compare intravenous chemotherapy versus intraperitoneal chemotherapy in patients with recurrent ovarian cancer.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- Female
- Target Recruitment
- 80
Inclusion Criteria
- women who had recurrent ovarian cancer and was treated with either intravenous or intraperitoneal platinum based chemotherapy
Exclusion Criteria
- women who did not complete the designated treatment course (exception to those who had to quit due to progressive disease or death of any cause)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description intravenous chemotherapy Chemotherapy triweekly chemotherapy with carboplatin AUC=5\~6 + liposomal-doxorubicin 30\~40mg/m2 or paclitaxel 175mg/m2 0r docetaxel 60\~75mg/m2 intraperitoneal chemotherapy Chemotherapy Day 1 IV Paclitaxel 135 mg/m2 + IP Cisplatin 75-100 mg/m2 or IP carboplatin (AUC = 6) Day 8 IP Paclitaxel 60 mg/m2 Every 21 days \* 6 cycles OR Day 1 IP Carboplatin AUC=5 or IP Cisplatin 50-75mg/m2 Day 2 IV Liposomal doxorubicin 15 mg/m2 + IP Liposomal doxorubicin 15 mg/m2 Every 28 days \* 6 cycles
- Primary Outcome Measures
Name Time Method RFS the time interval from the date of surgery or the start of chemotherapy to clinically defined recurrence, disease progression, death from any cause or last follow-up Recurrence free survival
OS the time interval from the date of surgery or the start of chemotherapy to the date of death from any cause or last follow-up Overall Survival
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Department of Obstetrics and Gynecology, Far Eastern Memorial Hospital
🇨🇳Banqiao, New Taipei, Taiwan