Intraocular Pressure and Optic Nerve Sheath Diameter Changes at Different PEEP Levels

Not Applicable

Terminated

• Conditions: Intracranial Pressure; Intraocular Pressure; Positive End-expiratory Pressure
• Interventions: Other: Positive end-expiratory pressure

• Registration Number: NCT03938402
• Lead Sponsor: Marmara University

Brief Summary

Positive end-expiratory pressure (PEEP) is sometimes used during perioperative period, as it has favourable effects on lung mechanics. Unfortunately, it has some negative effects on the patients, like increased intraabdominal, intrathoracic, intracranial and intraocular pressures. In this study the investigators aimed to investigate the effects of different PEEP levels on the patients' intraocular and intracranial pressures. Intraocular pressure will be measured by ocular tonometry, and intracranial pressure will be estimated by optic nerve sheath diameter measurement. The measurements will be performed in the operating room in the patients undergoing laparotomic surgery.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-04-27
• Study First Submitted QC: 2019-05-02
• Study First Posted: 2019-05-06
• Study Start: 2019-07-01
• Primary Completion: 2020-12-31
• Study Completion: 2020-12-31
• Status Verified: 2021-11
• Last Update Submitted: 2021-11-22
• Last Update Posted: 2021-12-03

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

• Patients undergoing laparotomy for gastrointestinal surgery
• American Society of Anesthesiologists (ASA) 1 or 2 physical status
• Elective surgery

Exclusion Criteria

• Patients with glaucoma
• ASA 3 or over physical status
• Emergency surgery

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
PEEP 10	Positive end-expiratory pressure	-
PEEP 15	Positive end-expiratory pressure	-
PEEP 5	Positive end-expiratory pressure	-

Primary Outcome Measures

Name	Time	Method
Changes in intraocular pressure	Throughout the operation (usually about 1.5 hours).	The physiological value for intraocular pressure is 10-20 mm Hg. Changes in intraocular pressure will be observed throughout the surgery, as will its relationship with the positive end-expiratory pressure application.
Changes in optic nerve sheath diameter	Throughout the operation (usually about 1.5 hours).	Changes in optic nerve sheath diameter will be observed throughout the surgery, as will its relationship with the positive end-expiratory pressure application.

Trial Locations

Locations (1)

Marmara University School of Medicine; 🇹🇷 Istanbul, Pendik, Turkey