The efficacy of minocycline as an adjunctive treatment in unipolar depression: A pilot study using change on MADRS as the primary outcome.

Mental Health Research Institute0 个研究点目标入组 80 人开始时间: 2012年3月9日最近更新: 2020年1月13日

试验速览

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•Aged 18 or over
•-Capacity to consent to the study and to follow its instructions and procedures
•-Fulfil the DSM-IV-TR diagnostic criteria for major depressive disorder, single episode or recurrent, as well as scoring 20 or over on the MADRS, at the baseline visit
•-Participants on antidepressant therapy need to have been on the same treatment for at least two weeks prior to randomisation
•-Utilising effective contraception (other than the contraceptive pill due to drug interactions) if female of child-bearing age and sexually active

•-Concurrent diagnosis of bipolar disorder I, II or NOS -Three or more failed adequate trials of antidepressant therapy for the current major depressive episode or ECT for the current major depressive episode -Known or suspected clinically unstable systemic medical disorder (including a pre-existing infectious illness requiring tetracycline antibiotic treatment) -Pregnancy or breastfeeding -Contraindications to tetracyclines, including allergy or other intolerance; prior tetracycline use within 2 months of baseline visit -Current treatment with >5 mg beta caretone or >300 micrograms retinol equivalent. -Current treatment with anticoagulants; -Current treatment with methoxyflurane -Current treatment with penicillin -Females of childbearing age currently relying solely on the contraceptive pill as contraception.

发起方

Mental Health Research Institute