Deprescribing in older community patients

Not Applicable

Completed

• Conditions: Polypharmacy; High drug burden index; Public Health - Health service research

• Registration Number: ACTRN12618000729224
• Lead Sponsor: niversity of Otago - Christchurch

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-05-02
• Study Completion: 2021-06-03
• Last Update Posted: 13 December 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 363

Inclusion Criteria

Aged 65 years and older
- Prescribed at least one anticholinergic or sedative medicine (i.e. have a drug burden index greater than or equal to 0.5) in the last year
- Reside within the Canterbury District Health Board (CDHB) or South Canterbury District Health Board (SCDHB) region and are currently undergoing or have had an InterRAI assessment in the previous 12 months

Exclusion Criteria

-Those who have dementia or have other indicators for psychiatric illnesses; as defined by the InterRAI data
- Those who have end of life care
- Those who are not frail, as determined by scoring zero on the frailty index

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary outcome will be the change in a participant’s DBI (deltaDBI) between the time of the baseline interRAI assessment (T1) and time of 6 months follow-up (T2; deltaDBI = DBI_T1 – DBI_T2). Data for the calculation will be collected by comparing medication use pre- and post- intervention. We will determine if there is a greater reduction in the DBI of participants in the experimental arm of the trial compared with participants with the same level of frailty in the control arm. <br>The Drug Burden Index is an internationally recognised measure of polypharmacy and takes into account the cumulative side effects of anticholinergic and sedative medications.[6 months after randomisation]

Secondary Outcome Measures

Name	Time	Method
umber of emergency department visits using the NZ national minimum dataset (a record of all ED visits)[6 months after randomisation];Total number of medications from the national (PHARMAC) record of medication dispensings. [6 months after randomisation];Mortality which will be obtained from the national mortality database.[3 months and 6 months after trail ends];Number of unplanned hospital admissions (will be obtained from the national minimum dataset)[Six months after randomisation]