Hepatic Manifestations and Effect of Long COVID-19 on Patients With Chronic Liver Disease

Active, not recruiting

• Conditions: COVID-19
• Interventions: Diagnostic Test: liver function , prothrombin time , INR , US .

• Registration Number: NCT04998214
• Lead Sponsor: Assiut University

Brief Summary

To measure the frequency of persistent liver dysfunction (raised liver enzymes, serum albumin, prothrombin time, etc) in recovered COVID -19 patients.

To compare the hepatic manifestations in post COVID -19 patients with and without liver disease

Detailed Description

The digestive tract, particularly the liver, has recently been reported to be affected by SARS-CoV-2. Although abnormal liver enzymes were regularly described as an extra-pulmonary clinical feature, and almost one half of patients experienced grades of hepatic injury. liver damage in patients with SARS infections was primarily manifested in the mild and moderate elevation of alanine and/or aspartate aminotransferases (ALT and AST) with some degree of hypoalbuminemia and hyperbilirubinemia during the early stage of the illness.

Study Timeline

• Study First Submitted: 2021-03-19
• Study First Submitted QC: 2021-08-09
• Study First Posted: 2021-08-10
• Study Start: 2021-08-19
• Status Verified: 2023-02
• Last Update Submitted: 2023-02-03
• Last Update Posted: 2023-02-06
• Primary Completion: 2023-04-01
• Study Completion: 2023-04-30

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 65

Inclusion Criteria

• Patients previously diagnosed by COVID 19 eg : PCR and / or HRCT chest, lab of more than 1 month duration.

Exclusion Criteria

• Patients less than 18 y.
• Patients with acute COVID 19.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
control group non cirrhotic	liver function , prothrombin time , INR , US .	compare liver function 1m after COVID-19 and that at beginning of infection
cirrhotic patients	liver function , prothrombin time , INR , US .	compare liver function 1m after COVID-19 and that at beginning of infection

Primary Outcome Measures

Name	Time	Method
to evaluate the long term effect of COVID 19 on the liver	1 month	to evaluate the changes in liver function (bilirubin ,liver enzymes , albumin , prothrombin time and INR in patients post COVID_19

Secondary Outcome Measures

Name	Time	Method
: Effect of COVID 19 on diseased liver	1 month	to evaluate the changes in liver function(bilirubin , liver enzymes , albumin , prothrombin time , INR) in cirrhotic post COVID_19

Trial Locations

Locations (1)

Faculty of Medicine; 🇪🇬 Assiut, Egypt