Efficacy of oral antibiotic prophylaxis in prevention of surgical site infection following skin lesion excisions at high risk of infection in general practice

Completed

• Conditions: Surgical site infections following skin lesion excisions from the lower limb or groin in general practice; Surgical site infections following skin lesion excisions from any site in diabetics in general practice; Infection - Studies of infection and infectious agents; Surgery - Other surgery; Metabolic and Endocrine - Diabetes

• Registration Number: ACTRN12611000595910
• Lead Sponsor: James Cook University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-06-09
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1. >18 yrs old
2. Capable of informed consent
3. Presenting for excision of a minor skin lesion from lower leg or groin OR Diabetic presenting for skin lesion excision from any site

Exclusion Criteria

Currently taking antibiotics or clinically indicated for antibiotic treatment following excision
Repair of lacerations or lesion considered contaminated/infected prior to surgery
Excision not requiring sutures (E.g. shave biopsy or curette)
Excision of sebaceous cyst
Patient unable to return for suture removal
Penicillin or cephalosporin allergy

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Presence or absence of wound infection defined as:<br>Purulent discharge from the wound must be present <br>OR<br>Atleast one of the following signs and symptoms of infection <br>Pain/Tenderness<br>Localised swelling<br>Heat<br>Erythema >1cm[When patients return for suture removal (10 days for excisions from back and shin, 7 days for all other sites) or earlier if patients re-present due to perceived infection (date which wound is assessed at will be recorded)]