ISRCTN12008159
Completed
未知
The effect of increased sodium intake with a carbohydrate-rich meal on glucose homeostasis in subjects without diabetes after bariatric surgery: A proof-of-concept, randomised, open-label, crossover study
niversity of Leicester0 sites12 target enrollmentJuly 23, 2020
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Prevention of hypoglycaemia in non-diabetic people who have had a gastric bypass
- Sponsor
- niversity of Leicester
- Enrollment
- 12
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Aged \>\=18 years old but less than 75 years old
- •2\. Subjects \>\=1 year after gastric bypass (RYGB)
- •3\. Able to understand written and spoken English
- •4\. Able to give informed consent
Exclusion Criteria
- •1\. Use of any glucose\-lowering medication (including insulin)
- •2\. Adrenal insufficiency and/or substitution with glucocorticoids
- •3\. eGFR \<\=60 ml/min/173 m²
- •4\. Recent active infection (an active infection will be any infection over the last 10 days)
- •5\. Current use of steroids
- •6\. Known liver cirrhosis or ALT \>2 times above upper normal limit
- •7\. Known primary or secondary hyperaldosteronism
- •8\. Moderate or severe hypertension during screening visit (Systolic Blood Pressure \>160 mmHg as average of 3 measurements)
- •9\. Established diagnosis of congestive heart failure
- •10\. Significant peripheral oedema on clinical examination at screening visit
Outcomes
Primary Outcomes
Not specified
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