Circadian mechanisms for selective serotonin reuptake inhibitor treatment responses

Not Applicable

• Conditions: depression; Mental Health - Depression

• Registration Number: ACTRN12621000581864
• Lead Sponsor: Monash University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-05-17
• Last Update Posted: 24 May 2021

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

A current diagnosis of depression
Willingness to undergo treatment with citalopram

Exclusion Criteria

Major medical conditions, current use of medications which may affect sleep or circadian rhythms, recent shit-work or travel across time-zones, a history of psychosis or a family history of bipolar disorder, current substance use disorder.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Melatonin suppression<br>Percent melatonin suppression will be calculated by comparing melatonin levels during a 100 lux light exposure to melatonin levels during a dark control (<1 lux). <br>Melatonin will be assessed from saliva samples taken hourly in the evening using radio-immunoassay (RIA). [Baseline and after 8 weeks of intervention (citalopram treatment)<br><br>Saliva samples for melatonin assay will be taken hourly between 3 hours before habitual bedtime, and 3 hours after habitual bedtime (individually timed for each patient). ]

Secondary Outcome Measures

Name	Time	Method
Pupil light responses<br>Sustained pupil responses during darkness following a ~5 minute blue light exposure (monochromatic light, peak nm=480). Assessed using a custom-built desk-mounted pupillometer. [baseline and after 8 weeks of intervention (citalopram treatment)]