Behavioral Therapy for Children and Adolescents With Tourette Syndrome

Not Applicable

Completed

• Conditions: Tourette Syndrome
• Interventions: Behavioral: habit reversal training (HRT)

• Registration Number: NCT03621059
• Lead Sponsor: Taipei Medical University

Brief Summary

Tourette Syndrome (TS) is a common neuropsychiatric disorder in childhood and adolescence, and often comorbid with psychiatric comorbidity. Antipsychotic medications are usually the first choices, but may associate with adverse effects. Behavioral intervention for TS has been shown to be an effective treatment for children and adolescents, yet have not been performed and evaluated using control trails in Taiwan.

Detailed Description

TS is a common neuropsychiatric disorder in childhood and adolescence, and often comorbid with psychiatric comorbidity. Antipsychotic medications are usually the first choices, but may associate with adverse effects. Behavioral intervention for TS has been shown to be an effective treatment for children and adolescents, yet have not been performed and evaluated using control trails in Taiwan. This study therefore was to evaluate the efficacy of a comprehensive behavioral intervention therapy on improving tics and tic-related impairment for children and adolescents with Tourette syndrome.

Study Timeline

• Study Start: 2015-01-01
• Primary Completion: 2016-09-30
• Study Completion: 2016-09-30
• Status Verified: 2018-08
• Study First Submitted: 2018-08-02
• Study First Submitted QC: 2018-08-07
• Last Update Submitted: 2018-08-07
• Study First Posted: 2018-08-08
• Last Update Posted: 2018-08-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 46

Inclusion Criteria

• DSM-5 Diagnostic Criteria For Tourette Syndrome
• Patients aged from 6-15 years who were diagnosed with TS or CTD,
• Never received any pharmacological treatment
• Ability to understand the study purpose and/or provide consent for participation independently and via a caregiver serving as a proxy

Exclusion Criteria

• Have been diagnosed with another mental illness,
• Had no physical or medical condition,
• Had been received CBIT or cognitive behavior therapy before.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Behavioral Therapy with TS	habit reversal training (HRT)	habit reversal training (HRT)

Primary Outcome Measures

Name	Time	Method
Eefficacy of a behavioral therapy on improving tics with Tourette syndrome	at 3rd month and 6rd months following treatment.	Behavioral intervention group led to a significantly greater decrease in total motor score on the Yale Global Tic Severity Scale .The gold-standard measure of tic severity in TS, the YGTSS is a clinician-completed measure consisting of a tic symptom checklist, motor and vocal tic severity ratings, and a global tic impairment rating. To ascertain tic severity ratings, the examiner rates five different dimensions of tic severity each on a 0-5 scale: tic number, frequency, duration, intensity, and complexity. Each of the dimensions is scored separately for motor and vocal tics to produce motor and vocal tic subscale scores (range 0-25). These subscales are then combined to produce a total tic severity score (range 0-50), with higher numbers indicating more severe tics. The YGTSS has demonstrated acceptable internal consistency and acceptable convergent and divergent validity).