Basal bolus insulin therapy in critically ill patients: A randomized controlled trial.
Phase 3
- Conditions
- Critically ill patients who will be admitted to medical intensive care unit and have capillary blood glucose within 180- 400 mg/dl.basal bolus insulin, critically ill patient, hyperglycemia
- Registration Number
- TCTR20230410009
- Lead Sponsor
- Khon Kaen University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending (Not yet recruiting)
- Sex
- All
- Target Recruitment
- 168
Inclusion Criteria
1. Adult age more than 18 years olds and
2. capillary blood glucose in between 180 - 400 mg/dl.
Exclusion Criteria
1) Patients need intravenous infusion insulin therapy
2)Continuous enteral feeding
3)Patients in a shock state with vasopressor and nothing per oral
4)Patient with Raynaud phenomenon, which interferes with capillary blood glucose measurement
5)Hypoglycemia prior admission
6)Chronic liver disease (child-pugh score B and C)
7)History of insulin allergy or anaphylaxis
8)Surgical patients
9)Known pregnancy
10) Patient who cannot consent form or identify LAR within 48 hr
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Capillary blood glucose in 140-180 mg per dL 28 days or until discharge from ICU Mean
- Secondary Outcome Measures
Name Time Method Mean daily CBG during study 28 days or until discharge from ICU Point of care test blood sugar,Glucose variability 28 days or until discharge from ICU Point of care test blood sugar,28 days overall mortality 28 days or until discharge from ICU Data from EMR or telephone interview,ICU length of stay 28 days or until discharge from ICU Data from EMR or telephone interview,Nosocomial infection 28 days or until discharge from ICU Data from EMR,Ventilator free day in 28 days 28 days or until discharge from ICU Data from EMR,Hypoglycemia less than 70 mg per dl 28 days or until discharge from ICU Point of care test blood sugar