Acute Effects of White Button and Shiitake Mushroom Powder Supplementation on Postprandial Lipemia and Glycemia Following a High-Fat Meal
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 16
- Primary Endpoint
- Postprandial Lipemia
Study Overview
Brief Summary
The goal of this clinical trial is to determine the acute effects on postprandial lipemia and glycemia by supplementing a high-fat meal with either white button (WB) or shiitake (SH) mushroom powder in relatively healthy adults, aged 18 to 35.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Treatment
- Masking
- Double (Participant, Investigator)
Masking Description
Double-blind, randomized
Eligibility Criteria
- Ages
- 18 Years to 35 Years (Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •generally healthy
- •non-diabetic
- •normal to mildly hypercholesterolemic (Total Cholesterol 200-239 mg/dL and LDL-C 130-159 mg/dL)
- •have BMI <30 or BF% (men <25%, women <32%)
- •no known disease of the liver or gallbladder
- •no documented problems with fat metabolism
- •normal lipemic response to a lipid challenge
- •No known mushroom allergy
Exclusion Criteria
- •liver disease
- •gallbladder disease
- •mushroom allergy
- •lipid disorder
Arms & Interventions
White Button Mushroom
368.5 grams of irradiated ground beef patty (80/20 lean mass to fat ratio) + 14 grams white button mushroom powder, and a Wegmans Food Market Brand Big Hawaiian bun
Intervention: Mushroom Powder (Dietary Supplement)
Shiitake Mushroom
368.5 grams of irradiated ground beef patty (80/20 lean mass to fat ratio) + 14 grams Shiitake mushroom powder, and a Wegmans Food Market Brand Big Hawaiian bun
Intervention: Mushroom Powder (Dietary Supplement)
Control
368.5 grams of irradiated ground beef patty (80/20 lean mass to fat ratio) and a Wegmans Food Market Brand Big Hawaiian bun.
Outcomes
Primary Outcomes
Postprandial Lipemia
Time Frame: Baseline, up to 6 hours postprandial
Total cholesterol, LDL, HDL, triglycerides
Postprandial Glycemia
Time Frame: Baseline, up to 6 hours postprandial
blood glucose
Secondary Outcomes
No secondary outcomes reported
Investigators
Lillian A. Talal
Principal Investigator
State University of New York at Buffalo