Optical screening for head-and-neck-, lung- and esophageal cancer

Completed

Conditions: eoplasmata in hoofd-halsgebied, longen en slokdarm
Lungcancer
throatcancer

Registration Number: NL-OMON43773

Lead Sponsor: Erasmus MC

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 168

Inclusion Criteria

In order to be eligible to participate in this study, a subject must meet all of the following criteria:;Patients with cancer:
* Diagnosis of a primary, untreated
1) SCC of the oropharynx or larynx, OR
2) Lung cancer (all types and stages), OR
3) Esophageal cancer (all types and stages)
* Age 18 or over
* Good understanding of Dutch or English;Specialism-related patients not suspected for cancer
* Diagnosis of
1) (Sino)nasal polyps OR nasal septum deviation/anomaly with an extended ENT-physical examination including fiber-optical endoscopy within the last 12 months OR
2) COPD, all stages with a CT-scan within the last 12 months OR
3) Patiënts with complaints of indigestion that underwent endoscopic examination of the esophagus
* Age 50 or over
* Good understanding of Dutch or English

Exclusion Criteria

A potential subject who meets any of the following criteria will be excluded from participation in this study if any of the following criteria are met:;*Cancer*-patiënts:
* Prior treatment of the tumor ((chemo)radiation therapy or other)
* Another type of tumor in the head and neck region (non SCC)
* Recurrence of the tumor (no-primary tumor)
* Patients with diagnosed HIV, CMV or Hepatitis C
* Serious other illness;Specialism-related non-malignant patients:
* Any suspection of (pre)malignant laesions at physical examination and clinical tests (e.g. CT-scan and endoscopy)
* Clinical signs of malignancies (e.g. loss of weight and night sweats).
* Patients with diagnosed HIV, CMV or Hepatitis C
* Serious other illness

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Optical scattering properties of buccal mucosa will be measured and compared<br /><br>between patients with and without distant malignancy. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Scattering properties will be related to nanostructural changes measured using<br /><br>electron microscopy on biopsy material (2 mm punch) taken from the site of the<br /><br>optical measurement.</p><br>