Potential Diagnostic and Prognostic Value of microRNAs for the Patients of Acute Coronary Syndrome
- Conditions
- Acute Coronary Syndrome
- Registration Number
- NCT02755207
- Brief Summary
The purpose of this study is to evaluate the potential diagnostic and prognosis value of circulating microRNAs compared with cTnI for suspected ACS patients at the emergency department (ED) and intensive care unit (ICU).
- Detailed Description
The present study is a single-center, prospective diagnostic study among patients presenting to the ED or ICU within 24 h of onset of chest pain suggestive of suspected ACS.
We propose to construct the biobank of ACS and evaluate the potential diagnostic value of circulating microRNAs compared with cTnI for suspected ACS patients. All the patients are to be followed up for 6 months. Final diagnosis was made by an expert panel cardiologist, based on all available clinical information including cTnI measurements, ECG, coronary angiography, cardiac exercise tests and information from hospital discharge letters.
The concentrations of microRNAs will be evaluated by quantitative reverse transcription PCR, using highly specific primers and hybridization probes.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 100
Suspected ACS patients (STEMI, NSTEMI, and UA):
Age>18 years; Informed consent.
Patients who will undergo immediate PCI; Pregnant and lactating women; Patients with mental disorders; Patients are using other experimental drugs; Refusal to provide informed.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Evaluate the diagnostic value of microRNAs in qPCR，in ACS Day 7
- Secondary Outcome Measures
Name Time Method Evaluate the prognostic value of microRNAs in ACS 6 months
Trial Locations
- Locations (1)
Ethics Committee of Xinhua Hospital
🇨🇳Shanghai, Shanghai, China