Impact of New Anthropometric Indices on Outcomes After Cardiac Surgery

• Conditions: Coronary Artery Disease; Anthropometry; Cardiometabolic Risk Factors; Cardiac Anesthesia; Cardiac Surgery

• Registration Number: NCT05403294
• Lead Sponsor: TC Erciyes University

Brief Summary

Obesity is associated with a number of risk factors for cardiovascular disease. Body mass index (BMI) is the most commonly recommended and used anthropometric measure to classify general obesity in clinical and epidemiological studies. It is widely accepted that obesity increases the risk of heart disease and is thought to be a risk factor for adverse outcomes after cardiac surgery. However, recent studies show paradoxical results, wherein obese patients can experience fewer adverse events and lower mortality than patients with normal-low body mass index(BMI) . The discriminative capacity of BMI has been criticized because it cannot distinguish muscle mass from fat mass, or reflect fat distribution . Alternatively, abdominal obesity indices, such as waist circumference (WC) and waist-to-height ratio (WHtR), have been suggested to be better predictor of cardiometabolic abnormalities because they modulate the limitation of BMI. However, they were insufficient in studies.For this reason, scientists turned to find a new anthropometric formula that could better detect obesity-related mortality and morbidity and they developed 2 new methods. Body Shape İndex (ABSI) is calculated using waist circumference, BMI and height parameters. Body Roundness İndex (BRI) is calculated using waist circumference and height parameters. These new indices may reflect visceral adiposity and strongly predict cardiovascular risk, postsurgical outcomes and resource utilisation.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-05-02
• Study First Submitted QC: 2022-05-30
• Study First Posted: 2022-06-03
• Status Verified: 2022-07
• Last Update Submitted: 2022-07-26
• Study Start: 2022-07-27
• Last Update Posted: 2022-07-28
• Primary Completion: 2022-10-01
• Study Completion: 2022-11-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 240

Inclusion Criteria

• open heart surgery
• voluntary patients

Exclusion Criteria

• emergency surgery
• off-pump or robotic surgery
• surgery requiring deep hypothermic circulatory arrest
• reluctant patients

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
permanent rhythm device insertion	within 30 days of the procedure	Number of Patients requiring insertion of a permanent device
cardiac arrest	within 30 days of the procedure	number of patients with cardiac arrest
mortality	within 30 days of the procedure	Number of death at 30 days after surgery
postoperative stroke	within 30 days of the procedure	Number of patients with postoperative stroke
new atrial fibrillation/flutter	within 30 days of the procedure	Number of Partients with new atrial fibrillation/flutter

Secondary Outcome Measures

Name	Time	Method
intensive care unit (ICU) readmissions	within 30 days of the procedure	number of patients with intensive care unit readmission
prolonged ventilation	within 30 days of the procedure	number of patients experiencing prolonged postoperative pulmonary ventilation (\>24 hours)
sepsis /deep sternal infection	within 30 days of the procedure	number of patients with sepsis, deep sternal wound infection or mediastinitis
total intensive care unit (ICU) hours	within 30 days of the procedure	total intensive care unit (ICU) hours
pulmonary complications	within 30 days of the procedure	number of patients with pneumonia or pleural effusion
renal failure / renal dialysis	within 30 days of the procedure	number of patient with acute renal failure or worsening renal function result