Evaluation of the Impact of Sleep Apnea on Cerebral Volumetry According to Age
- Conditions
- Obstructive Sleep Apnea (SAOS)Aging
- Interventions
- Device: Magnetic resonance imaging (MRI)Behavioral: Cognitive assessment
- Registration Number
- NCT02358811
- Brief Summary
Sleep apnea is a common disease in the general population and more particularly in elderly subjects in whom prevalence can reach 30 % after 70 years old. In adults (\<55 years old) cardiovascular consequences are well known and make sleep apnea treatment necessary. However elderly (\>70 years old) apneic subjects are less symptomatic in terms of sleepiness, they usually present a lower index of respiratory events and cardiovascular consequences in this population are still discussed, driving some authors to consider sleep apnea in the elderly as a specific disease and making the need for a treatment questionable.
In this study the investigators will focus on the comparison between adult and elderly apneic subjects in terms of cognitive and cardiovascular consequences. Adult apneic patients suffer from a decrease of cognitive performance as well as grey matter local atrophy, particularly in the hippocampus and in the frontal lobes. According to fewer studies, white matter can also be affected by a demyelinisation process. These structural modifications are sometimes associated with disorders of executive and memory functions. In the elderly, no clear association can be drawn between cognitive decline and sleep apnea. Moreover, to our knowledge, the cerebral state of elderly symptomatic apneic subjects has mostly not be investigated.
- Detailed Description
The goal of this project is to evaluate the impact of sleep apnea on the brain according to age. Our hypothesis is that adult apneic subjects would present local cerebral modification in the areas implied in cognition and memory, such as the hippocampus or the frontal areas, whereas elderly patients would present focal affects related to a deficit in the ventilatory and autonomic control without any major cognitive consequences.
Understanding the consequences of sleep apnea according to age could permit to refine the indications of sleep apnea treatment, mainly in elderly patients.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- Male
- Target Recruitment
- 69
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Eldery SAOS- Cognitive assessment People without obstructive sleep apnea (AHI\<10) 70 years old and more Adult SAOS- Cognitive assessment People without obstructive sleep apnea (AHI\<10) 18 \< Age \< 55 years old Eldery SAOS- Magnetic resonance imaging (MRI) People without obstructive sleep apnea (AHI\<10) 70 years old and more Adult SAOS+ Magnetic resonance imaging (MRI) Patients with severe obstructive sleep apnea (AHI\>30) 18 \< Age \< 55 years old Eldery SAOS+ Magnetic resonance imaging (MRI) Patients with severe obstructive sleep apnea (AHI\>30) 70 years old and more Eldery SAOS+ Cognitive assessment Patients with severe obstructive sleep apnea (AHI\>30) 70 years old and more Adult SAOS+ Cognitive assessment Patients with severe obstructive sleep apnea (AHI\>30) 18 \< Age \< 55 years old Adult SAOS- Magnetic resonance imaging (MRI) People without obstructive sleep apnea (AHI\<10) 18 \< Age \< 55 years old
- Primary Outcome Measures
Name Time Method Level of grey of each of the voxels of the cerebral grey matter During the MRI procedure We will use a technique widely used in neuroimage : the voxel-based morphometry (VBM) which allows a precise comparison by assessing local subtle differences at a voxel level (a voxel being a 3D-pixel).
- Secondary Outcome Measures
Name Time Method Level of grey of each of the voxels of the cerebral white matter During the MRI procedure We will use a technique widely used in neuroimage : the voxel-based morphometry (VBM) which allows a precise comparison by assessing local subtle differences at a voxel level (a voxel being a 3D-pixel).
Cognitive score At the inclusion It is the sum of the scores of the following tests :
* test of Stroop
* left Trail Making Test A and B
* verbal fluence test
* test of memory of figures direct and inverse in order
* completion of matrices
* Paced Auditory Serial Addition Test (PASAT)Dosage of the markers of the inflammation At the inclusion The blood markers of the inflammation are : C reactive protein (CRP US), Il1β, Il6, Il10, Tumor Necrosis Factor(TNFα) et Mitochondrial Pyruvate Carrier 1 (MPC1)
Trial Locations
- Locations (1)
CHU de Saint-Etienne
🇫🇷Saint-etienne, France