跳至主要内容
临床试验/NCT05632107
NCT05632107招募中不适用

Comparison of an Acceleromyography- and Electromyography-based Neuromuscular Monitor With TOF-Watch ® Monitor:a Pilot Study

Huazhong University of Science and Technology2 个研究点 分布在 1 个国家目标入组 100 人开始时间: 2023年3月1日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
入组人数
100
试验地点
2
主要终点
Assessing the correlation between the posttetanic count (PTC) obtained from the 2 devices

研究概览

简要总结

A quantitative neuromuscular monitoring device is desirable to titrate the depth of neuromuscular block (NMB) during a procedure, and to prevent residual effects after removal of the endotracheal tube. Unfortunately, the most widely used monitoring technique acceleromyography (AMG) typically implies a series of cumbersome installation and calibration procedures that frequently precludes correct use of these devices in clinical practice. Electromyography (EMG) has recently attracted a lot of attention as an alternative strategy to compensate for the deficiency of AMG-based neuromuscular monitors. Nowadays, a new technology that allows for the simultaneous acquisition of EMG and AMG signals is commercially available. Although its reliability has been rapidly accepted in Physical Medicine and Rehabilitation, the use of the technique in neuromuscular monitoring has never been reported. The aim of the present study is to assess the validity of the new device for estimating the neuromuscular block by comparing with TOF Watch®-SX, which is the most widely accepted AMG-based neuromuscular monitor that has been practiced in the clinical arena for decades.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 90 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Age less than 18 yr
  • American Society of Anesthesiologists Physical Status I to III
  • Elective surgery requiring muscle relaxation
  • Patients participated voluntarily and signed informed consent

排除标准

  • Patients with known neuromuscular disorder
  • Patients with a history of allergic reaction toneuromuscular blocking agents
  • Use of medications that might interfere with neuromuscular transmission
  • Any previous injury to the examined arm that might influence nerve conduction parameters
  • Pacemaker

结局指标

主要结局

Assessing the correlation between the posttetanic count (PTC) obtained from the 2 devices

时间窗: Perioperative data

Assessing the correlation between the train-of-four (TOF) obtained from the 2 devices

时间窗: Perioperative data

次要结局

  • Screening for eligible individual signal sources from the multiplex information of the new technology for improving neuromuscular monitoring(Perioperative data)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Hua Zheng

Associate Professor

Huazhong University of Science and Technology

研究点 (2)

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