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Clinical Trials/NCT05632107
NCT05632107
Recruiting
N/A

Comparison of an Acceleromyography- and Electromyography-based Neuromuscular Monitor With TOF-Watch ® Monitor:a Pilot Study

Huazhong University of Science and Technology4 sites in 1 country100 target enrollmentMarch 1, 2023

Overview

Phase
N/A
Intervention
Not specified
Conditions
Neuromuscular Blockade
Sponsor
Huazhong University of Science and Technology
Enrollment
100
Locations
4
Primary Endpoint
Assessing the correlation between the posttetanic count (PTC) obtained from the 2 devices
Status
Recruiting
Last Updated
29 days ago

Overview

Brief Summary

A quantitative neuromuscular monitoring device is desirable to titrate the depth of neuromuscular block (NMB) during a procedure, and to prevent residual effects after removal of the endotracheal tube. Unfortunately, the most widely used monitoring technique acceleromyography (AMG) typically implies a series of cumbersome installation and calibration procedures that frequently precludes correct use of these devices in clinical practice. Electromyography (EMG) has recently attracted a lot of attention as an alternative strategy to compensate for the deficiency of AMG-based neuromuscular monitors. Nowadays, a new technology that allows for the simultaneous acquisition of EMG and AMG signals is commercially available. Although its reliability has been rapidly accepted in Physical Medicine and Rehabilitation, the use of the technique in neuromuscular monitoring has never been reported. The aim of the present study is to assess the validity of the new device for estimating the neuromuscular block by comparing with TOF Watch®-SX, which is the most widely accepted AMG-based neuromuscular monitor that has been practiced in the clinical arena for decades.

Registry
clinicaltrials.gov
Start Date
March 1, 2023
End Date
December 1, 2027
Last Updated
29 days ago
Study Type
Observational
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Hua Zheng

Associate Professor

Huazhong University of Science and Technology

Eligibility Criteria

Inclusion Criteria

  • Age less than 18 yr
  • American Society of Anesthesiologists Physical Status I to III
  • Elective surgery requiring muscle relaxation
  • Patients participated voluntarily and signed informed consent

Exclusion Criteria

  • Patients with known neuromuscular disorder
  • Patients with a history of allergic reaction toneuromuscular blocking agents
  • Use of medications that might interfere with neuromuscular transmission
  • Any previous injury to the examined arm that might influence nerve conduction parameters
  • Pacemaker

Outcomes

Primary Outcomes

Assessing the correlation between the posttetanic count (PTC) obtained from the 2 devices

Time Frame: Perioperative data

Assessing the correlation between the train-of-four (TOF) obtained from the 2 devices

Time Frame: Perioperative data

Secondary Outcomes

  • Screening for eligible individual signal sources from the multiplex information of the new technology for improving neuromuscular monitoring(Perioperative data)

Study Sites (4)

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